β-Fibrinogen Gene −455G/A Polymorphism and Coronary Heart Disease Incidence: The Atherosclerosis Risk in Communities (ARIC) Study

Folsom, Aaron R; Aleksic, Nena; Ahn, Chul; Boerwinkle, Eric; Wu, Kenneth K

« Previous Next »Annals of Epidemiology
Volume 11, Issue 3 , Pages 166-170, April 2001

β-Fibrinogen Gene −455G/A Polymorphism and Coronary Heart Disease Incidence:

The Atherosclerosis Risk in Communities (ARIC) Study

Aaron R Folsom, MD
- Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, MN (A.R.F.); Division of Hematology (N.A., K.K.W.) and Section of Clinical Epidemiology (C.A.), University of Texas Medical School, Houston, TX USA
- and Human Genetics Center and Institute of Molecular Medicine, University of Texas, Houston Health Science Center, Houston, TX (E.B.) USA.
- Address reprint requests to: Aaron R. Folsom, M.D., Division of Epidemiology, School of Public Health, University of Minnesota, Suite 300, 1300 South Second Street, Minneapolis, Minnesota 55454–1015
Nena Aleksic, PharmD, PhD
- Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, MN (A.R.F.); Division of Hematology (N.A., K.K.W.) and Section of Clinical Epidemiology (C.A.), University of Texas Medical School, Houston, TX USA
- and Human Genetics Center and Institute of Molecular Medicine, University of Texas, Houston Health Science Center, Houston, TX (E.B.) USA.
Chul Ahn, PhD
- Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, MN (A.R.F.); Division of Hematology (N.A., K.K.W.) and Section of Clinical Epidemiology (C.A.), University of Texas Medical School, Houston, TX USA
- and Human Genetics Center and Institute of Molecular Medicine, University of Texas, Houston Health Science Center, Houston, TX (E.B.) USA.
Eric Boerwinkle, PhD
- Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, MN (A.R.F.); Division of Hematology (N.A., K.K.W.) and Section of Clinical Epidemiology (C.A.), University of Texas Medical School, Houston, TX USA
- and Human Genetics Center and Institute of Molecular Medicine, University of Texas, Houston Health Science Center, Houston, TX (E.B.) USA.
Kenneth K Wu, MD
- Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, MN (A.R.F.); Division of Hematology (N.A., K.K.W.) and Section of Clinical Epidemiology (C.A.), University of Texas Medical School, Houston, TX USA
- and Human Genetics Center and Institute of Molecular Medicine, University of Texas, Houston Health Science Center, Houston, TX (E.B.) USA.

Abstract

PURPOSE: The −455G/A (HaeIII) polymorphism of the β-fibrinogen gene influences levels of plasma fibrinogen. We determined whether it influences risk of coronary heart disease.

METHODS: We conducted a case-cohort study nested within a prospective investigation, the Atherosclerosis Risk in Communities Study. We accumulated 398 incident coronary heart disease cases over a median of 5.3 years of follow-up and compared their −455G/A status with a random sample of the cohort .

RESULTS: Plasma fibrinogen was higher in AA homozygous participants (341 mg/dL) than in persons carrying the G allele: GA (290 mg/dL), GG (298 mg/dL). However, there was no significant association between −455G/A and incident CHD.