Annals of Epidemiology
Volume 11, Issue 7 , Pages 512-518 , October 2001

Seroprevalence of Kaposi's Sarcoma-Associated Herpesvirus Infection among Blood Donors from Texas

  • Jacques Baillargeon, PhD

      Affiliations

    • J.B. and J.-H.D. contributed equally.
    • Department of Pediatrics, The University of Texas Health Science Center, San Antonio, TX USA
  • ,
  • Jian-Hong Deng, MD, MS

      Affiliations

    • J.B. and J.-H.D. contributed equally.
    • Department of Pediatrics, The University of Texas Health Science Center, San Antonio, TX USA
    • Department of Microbiology, The University of Texas Health Science Center, San Antonio, TX USA
  • ,
  • Evelyn Hettler, BS

      Affiliations

    • Department of Pediatrics, The University of Texas Health Science Center, San Antonio, TX USA
    • Department of Microbiology, The University of Texas Health Science Center, San Antonio, TX USA
  • ,
  • Chantal Harrison, MD

      Affiliations

    • Department of Pathology, The University of Texas Health Science Center, San Antonio, TX USA
  • ,
  • James J Grady, DrPH

      Affiliations

    • Department of Preventive Medicine and Community Health, University of Texas Medical Branch, Galveston, TX USA
  • ,
  • Laura G Korte, BS

      Affiliations

    • Gulf Coast Regional Blood Center, Houston, TX USA
  • ,
  • James Alexander, MD

      Affiliations

    • American Red Cross, Blood Services Texas Division, Dallas Donor Center, Dallas, TX USA
  • ,
  • Eduardo Montalvo, PhD

      Affiliations

    • Department of Pediatrics, The University of Texas Health Science Center, San Antonio, TX USA
  • ,
  • Hal B Jenson, MD

      Affiliations

    • Department of Pediatrics, The University of Texas Health Science Center, San Antonio, TX USA
    • Department of Microbiology, The University of Texas Health Science Center, San Antonio, TX USA
  • ,
  • Shou-Jiang Gao, PhD

      Affiliations

    • Department of Pediatrics, The University of Texas Health Science Center, San Antonio, TX USA
    • Department of Microbiology, The University of Texas Health Science Center, San Antonio, TX USA
    • Corresponding Author InformationAddress correspondences to: Dr. Shou-Jiang Gao, Department of Pediatrics, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900

Received 20 December 2000 ,Revised 23 March 2001 ,Accepted 6 April 2001.

References 

  1. Allain J-P. Screening blood donors for markers of new viruses. Lancet. 1997;349:584–585
  2. Sloand EM, Pitt E, Klein HG. Safety of the blood supply. JAMA. 1995;274:1368–1373
  3. Boshoff C, Whitby D, Hatziionnou T, Fisher C, van der Walt J, Hatzakis A, et al.  Kaposi's sarcoma-associated herpesvirus in HIV-negative Kaposi's sarcoma. Lancet. 1995;345:1043–1044
  4. Chang Y, Cesarman E, Pessin MS, Lee F, Culpepper J, Knowles D, et al.  Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science. 1994;266:1865–1869
  5. Chang Y, Ziegler JL, Wabinga H, Katongole-Mbidde E, Boshoff C, Whitby D, et al.  Kaposi's sarcoma-associated herpesvirus and Kaposi's sarcoma in Africa. Arch Intern Med. 1996;156:202–204
  6. Dupin N, Grandadam M, Calvez V, Gorin I, Aubin ST, Harvard S, et al.  Herpesvirus-like DNA in patients with Mediterranean Kaposi's sarcoma. Lancet. 1995;345:761–762
  7. Lebbé C, de Crémoux P, Rybojad M, Costa da Cunha C, Morel P, Calvo F. Kaposi's sarcoma and new herpesvirus. Lancet. 1995;345:1180
  8. Moore PS, Chang Y. Detection of herpesvirus-like DNA sequences in Kaposi's sarcoma lesions from persons with and without HIV infection. New Engl J Med. 1995;332:1181–1185
  9. Schalling M, Ekman M, Kaaya EE, Linde A, Bieberfeld P. A role for a new herpesvirus (KSHV) in different forms of Kaposi's sarcoma. Nature Med. 1995;1:707–708
  10. Cesarman E, Chang Y, Moore PS, Said JW, Knowles DM. Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas. New Engl J Med. 1995;332:1186–1191
  11. Nador RG, Cesarman E, Knowles DM, Said JW. Herpes-like DNA sequences in a body cavity-based lymphoma in an HIV-negative patient. New Engl J Med. 1995;333:943
  12. Pastore C, Gloghini A, Volpe G, Nomdedeu J, Leonardo E, Mazza U, et al.  Distribution of Kaposi's sarcoma herpesvirus sequences among lymphoid malignancies in Italy and Spain. Br J Haematol. 1995;91:918–920
  13. Karcher DS, Alkan S. Herpes-like DNA sequences, AIDS-related tumors, and Castelman's disease. New Engl J Med. 1995;333:797–798
  14. Soulier J, Grollet L, Oskenhendler E, Cacoub P, Cazais-Hatem D, Babinat P, et al.  Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's disease. Blood. 1995;86:1276–1280
  15. Gessain A, Sudaka A, Briere J, Fouchard N, Nicola M-A, Rio B, et al.  Kaposi's sarcoma-associated herpes-like virus (human herpesvirus type 8) DNA sequences in multicentric Castleman's disease (is there any relevant association in non-human immunodeficiency virus-infected patients?). Blood. 1996;87:414–416
  16. Chadburn A, Cesarman E, Nador RG, Liu Y. Kaposi's sarcoma-associated herpesvirus sequences in non-HIV-associated benign lymphoproliferative lesions. Lab Invest. 1996;74:109A
  17. Moore PS, Gao S-J, Dominguez G, Cesarman E, Lungu O, Knowles DM, et al.  Primary characterization of a herpesvirus-like agent associated with Kaposi's sarcoma. J Virol. 1996;70:549–558
  18. Russo JJ, Bohenzky RA, Chien M, Chen K, Maddalena D, Yan M, et al.  Nucleotide sequence of Kaposi's sarcoma-associated herpesvirus (HHV8). Proc Natl Acad Sci USA. 1996;93:14862–14867
  19. Klein G. Epstein-Barr Virus strategy in normal and neoplastic B cells. Cell. 1994;77:791–793
  20. Biesinger B, Muller FI, Simmer B, Lang G, Wittmann S, Platzer E, et al.  Stable growth transformation of human T lymphocytes by herpesvirus saimiri. Proc Natl Acad Sci USA. 1992;89:3116–3119
  21. Godden-Kent D, Talbot SJ, Boshoff C, Chang P, Moore R, Weiss A, et al.  The cyclin encoded by Kaposi's sarcoma-associated herpesvirus stimulates cdc6 to phosphorylate the retinoblastoma protein and histone H1. J Virol. 1997;71:4193–4198
  22. Cheng EH, Nicholas J, Bellows DS, Hayward GS, Guo HG, Reitz MS, et al.  A Bcl-2 homolog encoded by Kaposi's sarcoma-associated virus, human herpesvirus 8, inhibits apoptosis but does not heterodimerize with Bax or Bak. Proc Natl Acad Sci USA. 1997;94:690–694
  23. Sarid R, Sato T, Bohenzky R, Russo J, Chang Y. Kaposi's sarcoma-associated herpesvirus (KSHV) encodes a functional bcl-2 homolog. Nat Med. 1997;3:293–298
  24. Moore PS, Boshoff C, Weiss RA, Chang Y. Molecular mimicry of human cytokine and cytokine-response pathway genes by KSHV. Science. 1996;274:1739–1744
  25. Thome M, Schneider P, Hofmann K, Fickenscher H, Meinl E, Neipel F, et al.  Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors. Nature. 1997;386:517–521
  26. Arvanitakis L, Geras-Raaka E, Varma A, Gershengorn MC, Cesarman E. Human herpesvirus KSHV encodes a constitutively active G-protein-coupled receptor linked to cell proliferation. Nature. 1997;385:347–349
  27. Kledal TN, Rosenkilde MM, Coulin F, Simmons G, Johnsen AH, Alouani S, et al.  A broad-spectrum chemokine antagonist encoded by Kaposi's sarcoma-associated herpesvirus. Science. 1997;277:1656–1659
  28. Gao S-J, Boshoff C, Jayachandra S, Weiss RA, Chang Y, Moore PS. KSHV ORF K9 (vIRF) is an oncogene which inhibits the interferon signaling pathway. Oncogene. 1997;15:1979–1985
  29. Muralidhar S, Pumfery AM, Hassani M, Sadaie MR, Azumi N, Kishita M, et al.  Identification of Kaposin (open reading frame K12) as a human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus) transforming gene. J Virol. 1998;72:4980–4988
  30. Lee H, Guo J, Li M, Choi SK, DeMaria M, Rosenzweig M. Identification of an immunoreceptor tyrosine-based activation motif of K1 transforming protein of Kaposi's sarcoma-associated herpesvirus. Mol Cell Biol. 1998;18:5219–5228
  31. Flore O, Rafii S, Ely S, O'Leary JJ, Hyjek EM, Cesarman E. Transformation of primary human endothelial cells by Kaposi's sarcoma-associated herpesvirus. Nature. 1998;394:588–592
  32. Moses AV, Fish KN, Ruhl R, Smith PP, Strussenberg JG, Zhul L, et al.  Long-Term Infection and Transformation of Dermal Microvascular Endothelial Cells by Human Herpesvirus 8. J Virol. 1999;73:6892–6902
  33. Harrington JWJ, Bagasra O, Sosa CE, Bobroski LE, Baum M, Wen XL, et al.  Human herpesvirus type 8 DNA sequences in cell-free plasma and mononuclear cells of Kaposi's sarcoma patients. J Infect Dis. 1996;174:1101–1105
  34. Sirianni MC, Vincenzi L, Topino S, Scala A, Angeloni A, Gonnella R. Human herpesvirus 8 DNA sequences in CD8+ T cells. J Infect Dis. 1997;176:541
  35. Blackbourn DJ, Ambroziak J, Lennette E, Adams M, Ramachandran B, Levy JA. Infectious human herpesvirus 8 in a healthy North American blood donors. Lancet. 1997;349:609–611
  36. Bigoni B, Dolcetti R, de Lellis L, Carbone A, Boiocchi M, Cassai E, et al.  Human herpesvirus 8 is present in the lymphoid system of healthy persons and can reactivate in the course of AIDS. J Infect Dis. 1996;173:542–549
  37. Parravicini C, Olsen S, Capra M, Pati F, Sirchia G, Gao S-J, et al.  Risk of Kaposi's sarcoma associated-herpesvirus transmission from donor allograft among posttransplant Kaposi's sarcoma patients. Blood. 1997;90:2826–2829
  38. Regamey N, Tamm M, Binet I, Thiel G, Erb P, Cathomas G. Transplantation-associated Kaposi's sarcoma (herpesvirus 8 transmission through renal allografts). Transplant Proc. 1999;31:922–923
  39. Regamey N, Tamm M, Wernli M. Transmission of human herpesvirus 8 infection from renal-transplant donors to recipients. New Engl J Med. 1998;339:1353–1363
  40. Nocera A, Corbellino M, Valente U, Barocci S, Torre F, De Palma R, et al.  Posttransplant human herpes virus 8 infection and seroconversion in a Kaposi's sarcoma affected kidney recipient transplanted from a human herpes virus 8 positive living related donor. Transplant Proc. 1998;30:2095–2096
  41. Cannon MJ, Dollard SC, Smith DK, Klein RS, Schuman P, Rich JD, et al.  Blood-borne and sexual transmission of human herpesvirus 8 in women with or at risk for human immunodeficiency virus infection. New Engl J Med. 2001;344:637–643
  42. Moore PS, Kingsley L, Holmberg SD, Spira T, Conley LJ, Hoover D, et al.  KSHV infection prior to onset of Kaposi's sarcoma. AIDS. 1996;10:175–180
  43. Whitby D, Howard MR, Tenant-Flowers M, Brink NS, Copas A, Boshoff C, et al.  Detection of Kaposi's sarcoma associated herpesvirus in peripheral blood of HIV-infected individuals and progression to Kaposi's sarcoma. Lancet. 1995;364:799–802
  44. Gao S-J, Kingsley L, Hoover DR, Spira TJ, Rinaldo CR, Saah A, et al.  Seroconversion of antibodies against Kaposi's sarcoma-associated herpesvirus-related latent nuclear antigens before the development of Kaposi's sarcoma. New Engl J Med. 1996;335:233–241
  45. Gao S-J, Kingsley L, Li M, Zheng W, Parravicini C, Ziegler J, et al.  KSHV antibodies among Americans, Italians and Ugandans with and without Kaposi's sarcoma. Nat Med. 1996;2:925–928
  46. Kedes DH, Operskalski E, Busche M, Flood J, Kohn R, Ganem D. The seroepidemiology of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus) (distribution of infection in KS risk groups for sexual transmission). Nat Med. 1996;2:918–924
  47. Martin JN, Ganem DE, Osmond DH, Page-Shafer KA, Mavrae D, Kedes DH. Sexual transmission and the natural history of human herpesvirus 8 infection. New Engl J Med. 1998;338:948–954
  48. Melbye M, Cook PM, Hjalgrim H, Begtrup K, Simpson GR, Biggar RJ, et al.  Risk factors for Kaposi's-sarcoma-associated herpesvirus (KSHV/HHV-8) seropositivity in a cohort of homosexual men, 1981-1996. Int J Cancer. 1998;77:543–548
  49. Chatlynne LG, Lapps W, Handy M, Huang YQ, Masood R, Hamilton AS, et al.  Detection and titration of human herpesvirus-8-specific antibodies in sera from blood donors, acquired immunodeficiency syndrome patients, and Kaposi's sarcoma patients using a whole virus enzyme-linked immunosorbent assay. Blood. 1998;92:53–58
  50. Olsen SJ, Chang Y, Moore PS, Biggar RJ, Melbye M. Increasing Kaposi's sarcoma-associated herpesvirus seroprevalence with age in a highly Kaposi's sarcoma endemic region, Zambia in 1985. AIDS. 1998;12:1921–1925
  51. Simpson GR, Schulz TF, Whitby D, Cook PM, Bosnoff C, Rainbow L, et al.  Prevalence of Kaposi's sarcoma-associated herpesvirus infection measured by antibodies to recombinant capsid protein and latent immunofluorescence antigen. Lancet. 1996;348:1133–1138
  52. Smith NA, Sabin CA, Gopal R, Bourboulia D, Labbet W, Boshoff C, et al.  Serologic Evidence of Human Herpesvirus 8 Transmission by Homosexual but Not Heterosexual Sex. J Infect Dis. 1999;180:600–606
  53. Zhang X, Fitzpatrick L, Campbell TB, Badaro R, Schechter M, Melo M, et al.  Comparison of the prevalence of antibodies to human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus) in Brazil and Colorado. J Infect Dis. 1998;178:1488–1491
  54. Engels EA, Eastman H, Ablashi DV, Wilks RJ, Braham J, Manns A. Risk of tranfusion-associated transmission of human herpesvirus 8. J Natl Cancer Inst. 1999;91:1773–1775
  55. Zhang Y-J, Davis TL, Wang X-P, Deng J-H, Baillargeon J, Yen T, et al.  Distinct distribution of rare KSHV genotypes in South Texas (implications for KSHV epidemiology). J Infect Dis. 2001;183:125–129
  56. Gao S-J, Alsina M, Deng J-H, Harrison CR, Montairo EA, Leach LL, et al.  Antibodies to Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in patients with multiple myeloma. J Infect Dis. 1998;178:846–849
  57. Kleinbaum DG, Kupper LL, Muller KE. Applied Regression Analysis and Other Multivariable Methods. Belmont, CA: Duxbury Press; 1988;
  58. Cody RP, Smith JK. Applied Statistics and the SAS Programming Language. Upper Saddle River, NJ: Prentice Hall; 1991;
  59. Allain JP. Emerging viruses in blood transfusion. Vox Sang. 1998;74:125–129
  60. Belec L, Cancre N, Hallouin MC, Morvan J, Si Mohamed A, Gresenguet G. High prevalence in Central Africa of blood donors who are potentially infectious for human herpesvirus 8. Transfusion. 1998;38:771–775
  61. Blackbourn DJ, Ambroziak J, Lennette E, Adams M, Ramachandran B, Levy JA. Infectious human herpesvirus 8 in a healthy North American blood donors. Lancet. 1997;349:609–611
  62. Lin S-F, Sun R, Heston L, Gradoville L, Shedd D, Haglund K, et al.  Identification, expression, and immunogenicity of Kaposi's sarcoma-associated herpesvirus-encoded small viral capsid antigen. J Virol. 1997;71:3069–3076
  63. Zhu L, Wang R, Sweat A, Goldstein E, Horvat R, Chandran B. Comparison of human sera reactivities in immunoblots with recombinant human herpesvirus (HHV)-8 proteins associated with the latent (ORF73) and lytic (ORFs 65, K8.1A, and K8.1B) replicative cycles and in immunofluorescence assays with HHV-8-infected BCBL-1 cells. Virology. 1999;256:381–392
  64. Lennette ET, Blackbourne DJ, Levy JA. Antibodies to human herpesvirus type 8 in the general population and in Kaposi's sarcoma patients. Lancet. 1996;348:858–861
  65. Angeloni A, Heston L, Uccini S, Sirianni MC, Cottoni F, Masala MV, et al.  High prevalence of antibodies to human herpesvirus 8 in relatives of patients with classic Kaposi's sarcoma from Sardinia. J Infect Dis. 1998;177:1715–1718
  66. Rezza G, Lennette ET, Giuliani M, Pezzotti P, Caprilli F, Monini D, et al.  Prevalence and determinants of anti-lytic and anti-latent antibodies to human herpesvirus-8 among Italian individuals at risk of sexually and parenterally transmitted infections. Int J Cancer. 1998;77:361–365
  67. Perna AM, Bonura F, Vitale F, Viviano E, DiBenedetto MA, Ajello F, et al.  Antibodies to human herpes virus type 8 (HHV8) in general population and in individuals at risk for sexually transmitted diseases in Western Sicily. Int J Epidemiol. 2000;29:175–179
  68. Calabro ML, Sheldon J, Favero A, Simpson GR, Fiore JR, Gomes E, et al.  Seroprevalence of Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 in several regions of Italy. J Hum Virol. 1998;1:207–213
  69. Gessain A, Mauclere P, van Beveren M, Plancoulaine S, Ayouba A, Essame-Oyouo JL, et al.  Human herpesvirus 8 primary infection occurs during childhood in Cameroon, Central Africa. Int J Cancer. 1999;81:189–192
  70. Sitas F, Carrara H, Beral V, Newton R, Reeves G, Bull D, et al.  Antibodies against human herpesvirus 8 in black South African patients with cancer. New Engl J Med. 1999;340:1863–1871
  71. Wilkinson D, Sheldon J, Gilks CF, Schulz TF. Prevalence of infection with human herpesvirus 8/Kaposi's sarcoma herpesvirus in rural South Africa. S Afr Med J. 1999;89:554–557
  72. Miller G, Rigsby MO, Heston L, Grogan E, Sun R, Metaka C, et al.  Antibodies to butyrate-inducible antigens of Kaposi's sarcoma-associated herpesvirus in patients with HIV-1 infection. New Engl J Med. 1996;334:1292–1297
  73. Simonart T, Noel JC, Van Vooren JP, De Dobbeleer G. Classic Kaposi's sarcoma after multiple-partner heterosexual behavior in Central Africa. J Am Acad Dermatol. 1999;41:648–649
  74. Grulich AE, Olsen SJ, Luo K, Hendry O, Cunningham P, Cooper DA, et al.  Kaposi's sarcoma-associated herpesvirus (a sexually transmissible infection?). J AIDS Hum Retrovirol. 1999;20:387–393
  75. Smith MS, Bloomer C, Horvat R, Goldstein E, Casparian JM, Chandran B. Detection of human herpesvirus 8 DNA in Kaposi's sarcoma lesions and peripheral blood of human immunodeficiency virus-positive patients and correlation with serologic measurements. J Infect Dis. 1997;176:84–93
  76. Olsen SJ, Tarte K, Sherman W, Hale EE, Weisse MT, Orazi A, et al.  Evidence against KSHV infection in the pathogenesis of multiple myeloma. Virus Res. 1998;57:197–202
  77. He J, Bhat G, Kankasa C, Chintu C, Mitchell C, Duan W, et al.  Seroprevalence of human herpesvirus 8 among Zambian women of childbearing age without Kaposi's sarcoma (KS) and mother-child pairs with KS. J Infect Dis. 1998;178:1787–1790
  78. Evans AS. The history of infectious mononucleosis. Am J Med Sci. 1974;267:189–195
  79. Wang PS, Evans AS. Prevalence of antibodies to Epstein-Barr virus and cytomegalovirus in sera from a group of children in the People's Republic of China. J Infect Dis. 1986;153:150–152

PII: S1047-2797(01)00242-3

Annals of Epidemiology
Volume 11, Issue 7 , Pages 512-518 , October 2001