Annals of Epidemiology
Volume 15, Issue 3 , Pages 196-201 , March 2005

Cholecystokinin A Receptor Gene Promoter Polymorphism and Intelligence

Received 6 June 2004 ,Accepted 14 June 2004.

References 

  1. Hansen TV. Cholecystokinin gene transcription: Promoter elements, transcription factors, and signaling pathways. Peptides. 2001;22:1201–1211
  2. Hill DR, Shaw TM, Graham W, Woodruff GN. Autoradiographical detection of cholecystokinin-A receptors in primate brain using 125I-Bolton Hunter CCK-8 and 3H-MK-329. J Neurosci. 1990;10:1070–1081
  3. Brenner LA, Ritter RC. Type A CCK receptors mediate satiety effects of intestinal nutrients. Pharmacol Biochem Behav. 1996;54:625–631
  4. Lydiard RB. Neuropeptides and anxiety: Focus on cholecystokinin. Clin Chem. 1994;40:315–318
  5. Tachikawa H, Harada S, Kawanishi Y, Okubo T, Shiraishi H. Novel polymorphisms of the human cholecystokinin A receptor gene: An association analysis with schizophrenia. Am J Med Genet. 2000;96:141–145
  6. Nomoto S, Miyake M, Ohta M, Funakoshi A, Miyasaka K. Impaired learning and memory in OLETF rats without cholecystokinin (CCK)-A receptor. Physiol Behav. 1999;66:869–872
  7. Li XL, Aou S, Hori T, Oomura Y. Spatial memory deficit and emotional abnormality in OLETF rats. Physiol Behav. 2002;75:15–23
  8. Shimokata H, Ando F, Niino N. A new comprehensive study on aging—The National Institute for Longevity Sciences, Longitudinal Study of Aging (NILS-LSA). J Epidemiol. 2000;10:S1–S9
  9. Wechsler D. Wechsler Adult Intelligence Scale – Revised manual. New York: Psychological Corporation; 1981;
  10. Shinagawa F, Kobayashi S, Fujita K, Maekawa HH. Japanese Wechsler Adult Intelligence Scale–Revised. [in Japanese] Tokyo: Nihon-Bunka-Kagaku-Sha (Japan Culture and Science Company); 1990;
  11. Kobayashi S, Fujita K, Maekawa H, Dairoku H. Short form method in Japan. [in Japanese] In:  Misawa G editors. Japanese Wechsler Adult Intelligence Scale-Revised Short Forms. Tokyo: Nihon-Bunka-Kagaku-Sha (Japan Culture and Science Company); 1993;p. 23–55
  12. Funakoshi A, Miyasaka K, Matsumoto H, Yamamori S, Takiguchi S, Kataoka K, et al. Gene structure of human cholecystokinin (CCK) type-A receptor: Body fat content is related to CCK type-A receptor gene promoter polymorphism. FEBS Lett. 2000;466:264–266
  13. Fried I, Wilson CL, Morrow JW, Cameron KA, Behnke ED, Ackerson LC, et al. Increased dopamine release in the human amygdala during performance of cognitive tasks. Nat Neurosci. 2001;4:201–206
  14. Josselyn SA, Franco VP, Vaccarino FJ. Devazepide, a CCKA receptor antagonist, impairs the acquisition of conditioned reward and conditioned activity. Psychopharmacology. 1996;123:131–143
  15. Bouchard TJ, McGue M. Familial studies of intelligence: A review. Science. 1981;212:1055–1059
  16. Payton A, Holland F, Diggle P, Rabbitt P, Horan M, Davidson Y, et al. Cathepsin D exon 2 polymorphism associated with general intelligence in a healthy older population. Mol Psychiatry. 2003;8:14–18

 This work was supported in part by Research Grants for Longevity Sciences (12C-01) from the Ministry of Health and Welfare of Japan to Drs. H. Shimokata and A. Funakoshi.

PII: S1047-2797(04)00246-7

doi: 10.1016/j.annepidem.2004.06.007

Annals of Epidemiology
Volume 15, Issue 3 , Pages 196-201 , March 2005

Article Tools

* Image Usage & Resolution