Annals of Epidemiology
Volume 17, Issue 3 , Pages 217.e1-217.e12 , March 2007

Male and Female Circumcision Associated With Prevalent HIV Infection in Virgins and Adolescents in Kenya, Lesotho, and Tanzania

Received 6 July 2006 ,Accepted 17 October 2006.

References 

  1. Tengia-Kessy A, Msamanga GI, Moshiro CS. Assessment of behavioural risk factors associated with HIV infection among youth in Moshi rural district, Tanzania. East Afr Med J. 1998;75:528–532
  2. Korra A, Bejiga M, Tesfaye S. Socio-demographic profile and prevalence of HIV infection in VCT clients in Addis Ababa. Ethiopian J Health Dev. 2005;109–115
  3. Central Statistical Agency [Ethiopia] and ORC Macro. Ethiopia Demographic and Health Survey 2005. Addis Ababa, Ethiopia, and Calverton, Maryland, USA: Central Statistical Agency and ORC Macro; 2006;
  4. Buve A, Lagarde E, Carael M, Rutenberg N, Ferry B, Glynn JR, et al. Interpreting sexual behaviour data: validity issues in the multicentre study on factors determining the differential spread of HIV in four African cities. AIDS. 2001;15(Suppl 4):S117–S126
  5. National Statistical Office (NSO) [Malawi] and ORC Macro. Malawi Demographic and Health Survey 2004. Calverton, Maryland: NSO and ORC Macro; 2005;
  6. Auvert B, Ballard R, Campbell C, Carael M, Carton M, Fehler G, et al. HIV infection among youth in a South African mining town is associated with herpes simplex virus-2 seropositivity and sexual behaviour. AIDS. 2001;15:885–898
  7. Shisana O, Zungu-Dirwayi N, Toefy Y, Simbayi LC, Malik S, Zuma K. Marital status and risk of HIV infection in South Africa. S Afr Med J. 2004;94:537–543
  8. Pettifor AE, Rees HV, Steffenson A, Hlongwa-Madikizela L, MacPhail C, Vermaak K, et al. HIV and sexual behaviour among young South Africans: a national survey of 15–24 year olds. Johannesburg: Reproductive Health Research Unit, University of the Witwatersrand; 2004;http://www.kff.org/southafrica/upload/HIV-and-Sexual-Behaviour-Among-Young-South-Africans-A-National-Survey-of-15-24-Year-Olds.pdf
  9. Auvert B, Taljaard D, Lagarde E, Sobngwi-Tambekou J, Sitta R, Puren A. Randomized, controlled intervention trial of male circumcision for reduction of HIV infection risk: the ANRS 1265 Trial. PLoS Med. 2005;2:e298
  10. Auvert B, Sobngwi-Tambekou J, Taljaard D, Lagarde E, Puren A. Authors' reply. PLoS Med. 2006;3:e67
  11. Shisana O, Rehle T, Simbayi LC, Parker W, Zuma K, Bhana A, et al. South African National HIV Prevalence, HIV Incidence, Behavior and Communication Survey, 2005. Cape Town: HSRC Press.; 2005;http://www.cadre.org.za/pdf/SA-National-HIV-Survey.pdf
  12. Ministry of Health (MOH) [Uganda] and ORC Macro. Uganda HIV/AIDS Sero-behavioural Survey 2004–2005. Calverton, Maryland, USA: Ministry of Health and ORC Macro; 2006;
  13. Lopman BA, Garnett GP, Mason PR, Gregson S. Individual level injection history: a lack of association with HIV incidence in rural Zimbabwe. PLoS Med. 2005;2:e37
  14. Kumwenda N, Hoffman I, Chirenje M, Kelly C, Coletti A, Ristow A, et al. HIV incidence among women of reproductive age in Malawi and Zimbabwe. Sex Transm Dis. 2006;33:646–651
  15. Siegfried N, Muller M, Deeks J, Volmink J, Egger M, Low N, et al. HIV and male circumcision–a systematic review with assessment of the quality of studies. Lancet Infect Dis. 2005;5:165–173
  16. Morgan D, Mahe C, Mayanja B, Okongo JM, Lubega R, Whitworth JA. HIV-1 infection in rural Africa: is there a difference in median time to AIDS and survival compared with that in industrialized countries?. AIDS. 2002;16:597–603
  17. Central Bureau of Statistics (CBS) [Kenya], Ministry of Health [Kenya], ORC Macro. Kenya Demographic and Health Survey 2003. Calverton, MD: CBS, MOH, and ORC Marco; 2004;
  18. Ministry of Health and Social Welfare (MOHSW) [Lesotho], Bureau of Statistics (BOS), ORC Macro. Lesotho Demographic and Health Survey 2004. Calverton, MD: MOHSW, BOS, ORC Macro; 2005;
  19. Tanzania Commission for AIDS (TACAIDS), National Bureau for Statistics (NBS), ORC Macro. Tanzania HIV/AIDS Indicator Survey 2003-04. Calverton, Maryland: TACAIDS, NBS, and ORC Macro; 2005;
  20. Nyong'a V. Female circumcision. Kenya demographic and health survey, 1998. Calverton, Maryland: Central Bureau of Statistics, Kenya and Macro International; 1999;167–174
  21. Kraemer HC. Reconsidering the odds ratio as a measure of 2x2 association in a population. Stat Med. 2004;23:257–270
  22. Rutledge T, Loh C. Effect sizes and statistical testing in the determination of clinical significance in behavioral medicine research. Ann Behav Med. 2004;27:138–145
  23. Goodman LA, Kruskal WH. Measures of association for cross classifications. J Am Stat Assoc. 1954;49:732–764
  24. Agresti A, Finlay B. Statistical methods for the social sciences. San Francisco: Dellen Publishing Company; 1986;
  25. Rosenthal R. Meta-analytic procedures for social research. Newbury Park: Sage; 1991;
  26. Schmidt FL, Hunter JE, Raju NS. Validity generalization and situational specificity: a second look at the 75% rule and Fisher's z transformation. J Appl Psychol. 1988;73:665–672
  27. Schield M, Burnham TVV. Algebraic relationships between relative risk, phi and measures of necessity and sufficiency in a 2 × 2 table. Proceedings of the 2002 meeting of the American Statistical Association, Section on Statistical Education; 2002, http://web.augsburg.edu/∼schield/MiloPapers/2002JSM.pdf.
  28. Ameh EA, Sabo SY, Muhammad I. Amputation of the penis during traditional circumcision. Trop Doct. 1997;27:117
  29. du Toit DF, Villet WT. Gangrene of the penis after circumcision: a report of 3 cases. S Afr Med J. 1979;55:521–522
  30. Eason JD, McDonnell M, Clark G. Male ritual circumcision resulting in acute renal failure. BMJ. 1994;309:660–661
  31. Lagarde E, Dirk T, Puren A, Reathe RT, Bertran A. Acceptability of male circumcision as a tool for preventing HIV infection in a highly infected community in South Africa. AIDS. 2003;17:89–95
  32. Mayatula V, Mavundla TR. A review on male circumcision procedures among South African blacks. Curationis. 1997;20:16–20
  33. Ahmed A, Mbibi NH, Dawam D, Kalayi GD. Complications of traditional male circumcision. Ann Trop Paediatr. 1999;19:113–137
  34. Crowley IP, Kesner KM. Ritual circumcision (Umkhwetha) amongst the Xhosa of the Ciskei. Br J Urol. 1990;66:318–321
  35. Magoha GA. Circumcision in various Nigerian and Kenyan hospitals. East Afr Med J. 1999;76:583–586
  36. Sidley P. Botched circumcisions lead to arrest for murder. BMJ. 1996;313:647
  37. Sylla C, Diao B, Diallo AB, Fall PA, Sankale AA, Ba M. [Complications of circumcision. Report of 63 cases]. Prog Urol. 2003;13:266–272
  38. van Vuuren CJ, de Jongh M. Rituals of manhood in South Africa: circumcision at the cutting edge of critical intervention. S Afr J Ethnol. 1999;22:142–156
  39. Fennell WM. A perspective on AIDS. S Afr Med J. 1991;79:626
  40. Aweis D, Brabin BJ, Beeching NJ, Bunn JE, Cooper C, Gardner K, et al. Hepatitis B prevalence and risk factors for HBsAg carriage amongst Somali households in Liverpool. Commun Dis Public Health. 2001;4:247–252
  41. Habib M, Mohamed MK, Abdel-Aziz F, Magder LS, Abdel-Hamid M, Gamil F, et al. Hepatitis C virus infection in a community in the Nile Delta: risk factors for seropositivity. Hepatology. 2001;33:248–253
  42. Kefene H, Rapicetta M, Rossi GB, Bisanti L, Bekura D, Morace G, et al. Ethiopian National Hepatitis B Study. J Med Virol. 1988;24:75–84
  43. Medhat A, Shehata M, Magder LS, Mikhail N, Abdel-Baki L, Nafeh M, et al. Hepatitis C in a community in Upper Egypt: risk factors for infection. Am J Trop Med Hyg. 2002;66:633–638
  44. Otkun M, Erdogan MS, Tatman-Otkun M, Akata F. Exposure time to hepatitis B virus and associated risk factors among children in Edirne, Turkey. Epidemiol Infect. 2005;133:509–516
  45. Stoszek SK, Abdel-Hamid M, Narooz S, Daly ME, Saleh DA, Mikhail N, et al. Prevalence of and risk factors for hepatitis C in rural pregnant Egyptian women. Trans R Soc Trop Med Hyg. 2006;100:102–107
  46. Tsega E, Tsega M, Mengesha B, Nordenfelt E, Hansson BG, Lindberg J. Transmission of hepatitis B virus infection in Ethiopia with emphasis on the importance of vertical transmission. Int J Epidemiol. 1988;17:874–879
  47. Ministry of Health, Republic of Kenya . First National Congress on Quality Improvement in Health Care, Medical Research, and Traditional Medicine, Final Congress Report. Nairobi: Ministry of Health; 2001;
  48. Elmusharaf S, Elkhidir I, Hoffmann S, Almroth L. A case-control study on the association between female genital mutilation and sexually transmitted infections in Sudan. BJOG. 2006;113:469–474
  49. Klouman E, Manongi R, Klepp KI. Self-reported and observed female genital cutting in rural Tanzania: associated demographic factors, HIV and sexually transmitted infections. Trop Med Int Health. 2005;10:105–115
  50. Gisselquist D, Rothenberg R, Potterat J, Drucker E. HIV infections in sub-Saharan Africa not explained by sexual or vertical transmission. Int J STD AIDS. 2002;13:657–666
  51. St. Lawrence JS, Klaskala W, Kankasa C, West JT, Mitchell CD, Wood C. Factors associated with HIV prevalence in a pre-partum cohort of Zambian women. Int J STD AIDS. 2006;17:607–613
  52. Deuchert E, Brody S. The role of health care in the spread of HIV/AIDS in sub-Saharan Africa: Evidence from Kenya. Int J STD AIDS. 2006;17:749–752
  53. Lane T, Pettifor A, Pascoe S, Fiamma A, Rees H. Heterosexual anal intercourse increases risk of HIV infection among young South African men. AIDS. 2006;20:123–125
  54. Shisana O, Mehtar S, Mosala T, Zungu-Dirwayi N, Rehle T, Dana P, et al. HIV risk exposure in children: a study of 2-9 year-olds served by public health facilities in the Free State, South Africa. Cape Town: HSRC Press; 2005;http://www.hsrcpress.ac.za/full_title_info.asp?id=2089
  55. Omotade O, Olaleye DO, Saliu L, Odaibo NG, Adeyemo AA. Human immunodeficiency seropositivity among mother-child pairs in South West Nigeria: a community-based survey. West Afr J Med. 2001;20:232–236
  56. Kelly R, Kiwanuka N, Wawer MJ, Serwadda D, Sewankambo NK, Wabwire-Mangen F, et al. Age of male circumcision and risk of prevalent HIV infection in rural Uganda. AIDS. 1999;13:399–405
  57. Auvert B, Buve A, Lagarde E, Kahindo M, Chege J, Rutenberg N, et al. Male circumcision and HIV infection in four cities in sub-Saharan Africa. AIDS. 2001;15(Suppl 4):S31–S40
  58. de Walque D. The determinants of HIV infection and sexual behaviors in Burkina Faso, Cameroon, Ghana, Kenya, and Tanzania. World Bank Policy Research Working Paper 3844. Washington, D.C.: World Bank; 2006;http://econ.worldbank.org
  59. Palme IB, Gudetta B, Degefu H, Bruchfeld J, Muhe L, Giesecke J. Risk factors for human immunodeficiency virus infection in Ethiopian children with tuberculosis. Pediatr Infect Dis J. 2001;20:1066–1072
  60. Quigley M, Munguti K, Grosskurth H, Todd J, Mosha F, Senkoro K, et al. Sexual behaviour patterns and other risk factors for HIV infection in rural Tanzania: a case-control study. AIDS. 1997;11:237–248
  61. Siegfried N, Muller M, Volmink J, Deeks J, Egger M, Low N, et al. Male circumcision for prevention of heterosexual acquisition of HIV in men. Cochrane Database Syst Rev. 2003;CD003362
  62. Stallings RY, Karugendo E. Female circumcision and HIV infection in Tanzania: for better or for worse? Abstract no. TuOa0401, 3rd IAS Conference on HIV Pathogenesis and Treatment, Rio de Janeiro, July, 2005; www.ias-2005.org/planner/Presentations/ppt/3138.ppt.
  63. Kapiga SH, Sam NE, Shao JF, Renjifo B, Masenga EJ, Kiwelu IE, et al. HIV-1 epidemic among female bar and hotel workers in northern Tanzania: risk factors and opportunities for prevention. J Acquir Immune Defic Syndr. 2002;29:409–417
  64. Msuya SE, Mbizvo E, Hussain A, Sundby J, Sam NE, Stray-Pedersen B. Female genital cutting in Kilimanjaro, Tanzania: changing attitudes?. Trop Med Int Health. 2002;7:159–165
  65. Sentjens RE, Sisay Y, Vrielink H, Kebede D, Ader HJ, Leckie G, et al. Prevalence of and risk factors for HIV infection in blood donors and various population subgroups in Ethiopia. Epidemiol Infect. 2002;128:221–228
  66. Urassa M, Todd J, Boerma JT, Hayes R, Isingo R. Male circumcision and susceptibility to HIV infection among men in Tanzania. AIDS. 1997;11:73–80
  67. Nnko S, Washija R, Urassa M, Boerma JT. Dynamics of male circumcision practices in northwest Tanzania. Sex Transm Dis. 2001;28:214–218
  68. Brewer DD, Hagan H, Sullivan DG, Muth SQ, Hough ES, Feuerborn NA, et al. Social structural and behavioral underpinnings of hyperendemic Hepatitis C virus transmission in drug injectors. J Infect Dis. 2006;194:764–772
  69. Mattson CL, Muga R, Poulussen R, Onyango T, Bailey RC. Feasibility of medical male circumcision in Nyanza Province, Kenya. East Afr Med J. 2004;81:230–235
  70. Simonsen L, Kane A, Lloyd J, Zaffran M, Kane M. Unsafe injections in the developing world and transmission of bloodborne pathogens: a review. Bull World Health Organ. 1999;77:789–800
  71. Hauri AM, Armstrong GL, Hutin YJ. The global burden of disease attributable to contaminated injections given in health care settings. Int J STD AIDS. 2004;15:7–16
  72. Moore A, Herrera G, Nyamongo J, Lackritz E, Granade T, Nahlen B, et al. Estimated risk of HIV transmission by blood transfusion in Kenya. Lancet. 2001;358:657–660
  73. Vos J, Gumodoka B, van Asten HA, Berege ZA, Dolmans WM, Borgdorff MW. Improved injection practices after the introduction of treatment and sterility guidelines in Tanzania. Trop Med Int Health. 1998;3:291–296
  74. Gumodoka B, Vos J, Berege ZA, van Asten HA, Dolmans WM, Borgdorff MW. Injection practices in Mwanza Region, Tanzania: prescriptions, patient demand and sterility. Trop Med Int Health. 1996;1:874–880
  75. Daly AD, Nxumalo MP, Biellik RJ. An assessment of safe injection practices in health facilities in Swaziland. S Afr Med J. 2004;94:194–197
  76. Adejuyigbe EA, Durosinmi MA, Onyia FN, Adeodu OO. Blood transfusion related paediatric HIV/AIDS in Ile-Ife, Nigeria. AIDS Care. 2003;15:329–335
  77. Chipimo M, Mulamfu E, Mulenga M, Zhuzhuni A. Maternal and child health. In: Central Statistical Office [Zambia], Central Board of Health [Zambia], ORC Macro, eds. Calverton, Maryland: Central Statistical Office, Central Board of Health, and ORC Macro, 2003.
  78. Wolde Gebriel Y. Assessment of the safety of injections and related medical practices in health institutions in Sidama Zone, SNNPR. MPH thesis, Department of Community Health, Addis Ababa University; 2004.
  79. Ozdemir E. Significantly increased complication risks with mass circumcisions. Br J Urol. 1997;80:136–139
  80. World Health Organization . Report of the Global Injection Safety and Injection Control Meeting, 14–16 November, 2005, Sofitel Hotel, Hanoi, Vietnam. Geneva: World Health Organization; 2006;http://www.who.int/injection_safety/Final-SIGNHanoiReport7Feb06.pdf
  81. Gisselquist D, Friedman E, Potterat JJ, Minkin SF, Brody S. Four policies to reduce HIV transmission through unsterile health care. Int J STD AIDS. 2003;14:717–722
  82. National Bureau for Statistics (NBS), ORC Macro. Tanzania Demographic and Health Survey 2004-05. Dar es Salaam: National Bureau of Statistics and ORC Macro; 2005;
  83. Bishop YMM, Fienberg SE, Holland PW. Discrete multivariate analysis. Cambridge, MA: MIT Press; 1975;
  84. Mosteller F, Bush RR. Selected quantitative techniques. In:  Lindzey G editors. Handbook of social psychology. Cambridge, Mass: Addison-Wesley Publishing Company, Inc.; 1954;p. 289–334
  85. Sahu GK, McNearney T, Evans A, Turner A, Weaver S, Huang JC, et al. Transient or occult HIV infections may occur more frequently than progressive infections: changing the paradigm about HIV persistence. Arch Virol Suppl. 2005;131–145
  86. Tenenbaum SA, Morris CA, Alexander SS, McFerrin HE, Garry RF, Leissinger CA. Evidence of HIV exposure and transient seroreactivity in archived HIV-negative severe hemophiliac sera. Virol J. 2005;2:65
  87. Clerici M, Clark EA, Polacino P, Axberg I, Kuller L, Casey NI, et al. T-cell proliferation to subinfectious SIV correlates with lack of infection after challenge of macaques. AIDS. 1994;8:1391–1395
  88. Salvato MS, Emau P, Malkovsky M, Schultz KT, Johnson E, Pauza CD. Cellular immune responses in rhesus macaques infected rectally with low dose simian immunodeficiency virus. J Med Primatol. 1994;23:125–130
  89. Trivedi P, Horejsh D, Hinds SB, Hinds PW, Wu MS, Salvato MS, et al. Intrarectal transmission of simian immunodeficiency virus in rhesus macaques: selective amplification and host responses to transient or persistent viremia. J Virol. 1996;70:6876–6883
  90. Clerici M, Levin JM, Kessler HA, Harris A, Berzofsky JA, Landay AL, et al. HIV-specific T-helper activity in seronegative health care workers exposed to contaminated blood. JAMA. 1994;271:42–46
  91. Pinto LA, Sullivan J, Berzofsky JA, Clerici M, Kessler HA, Landay AL, et al. ENV-specific cytotoxic T lymphocyte responses in HIV seronegative health care workers occupationally exposed to HIV-contaminated body fluids. J Clin Invest. 1995;96:867–876
  92. Singh-Grewal D, Macdessi J, Craig J. Circumcision for the prevention of urinary tract infection in boys: a systematic review of randomised trials and observational studies. Arch Dis Child. 2005;90:853–858
  93. Weiss HA, Thomas SL, Munabi SK, Hayes RJ. Male circumcision and risk of syphilis, chancroid, and genital herpes: a systematic review and meta-analysis. Sex Transm Infect. 2006;82:101–109
  94. Zulu KP. Anal sex and HIV - an ignored tragedy, a case of Zambia. Abstract No. MoPe10.7P03, 3rd International AIDS Society Conference on HIV Pathogenesis and Treatment, Rio de Janeiro, July 24–27, 2005.
  95. Lorway R. Dispelling “heterosexual African AIDS“ in Namibia: Same-sex sexuality in the township of Katutura. Cult Health Sex. 2006;8:435–449
  96. Potterat JJ, Brewer DD, Muth SQ, Brody S. The protective effect of male circumcision as a faith lift for the troubled paradigm of HIV epidemiology in sub-Saharan Africa. PLoS Med. 2006;3:e64
  97. USAID/AIDSMark . Male Circumcision: Current Epidemiological and Field Evidence: Program and Policy Implications for HIV Prevention and Reproductive Health. Conference report. Washington, D.C.: USAID; 2003;
  98. Glynn JR, Carael M, Auvert B, Kahindo M, Chege J, Musonda R, et al. Why do young women have a much higher prevalence of HIV than young men? A study in Kisumu, Kenya and Ndola, Zambia. AIDS. 2001;15(Suppl 4):S51–S60

PII: S1047-2797(06)00265-1

doi: 10.1016/j.annepidem.2006.10.010

Annals of Epidemiology
Volume 17, Issue 3 , Pages 217.e1-217.e12 , March 2007