Moderate Alcohol Consumption and Risk of Developing Dementia in the Elderly: The Contribution of Prospective Studies

doi:10.1016/j.annepidem.2007.01.010

Annals of Epidemiology

Volume 17, Issue 5, Supplement, May 2007, Pages S43-S45

https://doi.org/10.1016/j.annepidem.2007.01.010 Get rights and content

Moderate alcohol consumption, after controlling for potential confounding factors, has been found to be associated with a lower risk of developing dementia in several prospective epidemiological studies from Europe, the United States, and China. When the type of alcoholic beverage consumed is analyzed, moderate wine intake has been systematically associated with lower risk. However, moderate consumption has very different definitions across studies, ranging from monthly or weekly drinking to 3 to 4 drinks per day. In addition, different results have been observed according to sex; some studies found the same effect in men and women, while others found either no association or a stronger association in women. All of these results lead to the conclusion that the observed association is fragile and needs further confirmation.

References (8)

A. Ruitenberg et al.
Alcohol consumption and risk of dementia: the Rotterdam Study
Lancet
(2002)
W. Huang et al.
Alcohol consumption and incidence of dementia in a community sample aged 75 years and older
J Clin Epidemiol
(2002)
J. Deng et al.
A 2-year follow-up study of alcohol consumption and risk of dementia
Clin Neurol Neurosurg
(2006)
J.M. Orgogozo et al.
Wine consumption and dementia in the elderly: a prospective community study in the Bordeaux area
Rev Neurol
(1997)

There are more references available in the full text version of this article.

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: Disclosure: Dr. Letenneur received a grant from the Office National Interprofessionnel des Vins (ONIVINS) to analyze the association between alcohol consumption and cardiovascular diseases. It was not linked to the study of dementia.

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Moderate Alcohol Consumption and Risk of Developing Dementia in the Elderly: The Contribution of Prospective Studies

Lancet

J Clin Epidemiol

Clin Neurol Neurosurg

Wine consumption and dementia in the elderly: a prospective community study in the Bordeaux area

Rev Neurol