Annals of Epidemiology
Volume 17, Issue 5, Supplement , Pages S49-S54 , May 2007

Moderate Drinking, Inflammation, and Liver Disease

  • Gyongyi Szabo, MD, PhD

      Affiliations

    • Corresponding Author InformationAddress correspondence to: Gyongyi Szabo, MD, PhD, Hepatology and Liver Center, University of Massachusetts Medical School, 364 Plantation St, Worcester, MA 01605.

References 

  1. Orholm M, Sorensen TI, Bentsen K, Hoybye G, Eghoje K, Christoffersen P. Mortality of alcohol abusing men prospectively assessed in relation to history of abuse and degree of liver injury. Liver. 1985;5:253–260
  2. Becker U, Deis A, Thorkild IA, Gronbaek M, Borch-Johnson K, Muller CF, et al. Prediction of risk of liver disease by alcohol intake, sex and age: A prospective populations study. Hepatology. 1996;23:1025–1029
  3. Fuchs CS, Deis A, Sorensen TI. Prediction of risk of liver disease by alcohol intake, sex, and age: a prospective population study. Hepatology. 1995;332:1245–1250
  4. McCullough AJ. Alcoholic liver disease. In:  Schiff ER,  Sorrell FF,  Maddrey WC editor. Schiff's Diseases of the liver. Philadelphia: Lippincott, Raven; 1999;p. 941–971
  5. Teli MR, Day CP, Burt AD, Bennett MK, James OF. Determination of progression to cirrhosis or fibrosis in pure alcoholic fatty liver. Lancet. 1995;14:987–990
  6. Fromenty B, Grimbert S, Mansouri A, Beaugrand M, Erlinger S, Rotig A, et al. Hepatic mitochondrial DNA deletion in alcoholics: association with microvesicular steatosis. Gastroenterology. 1995;108:193–200
  7. Kondili LA, Taliani G, Cerga G, Tosti ME, Babameto A, Resuli B. Correlation of alcohol consumption with liver histological features in non-cirrhotic patients. Eur J Gastroenterol Hepatol. 2005;17:155–159
  8. Corrao G, Bagnardi V, Zambon A, Arico S. Exploring the dose-response relationship between alcohol consumption and the risk of several alcohol-related conditions: a meta analysis. Addiction. 1999;94:1551–1573
  9. Lelbach WK. Cirrhosis in the alcoholic and its relation to the volume of alcohol abuse. Ann N Y Acad Sci. 1975;252:85–105
  10. Savolainen V, Liesto K, Mannikko A, Penttila A, Karhunen PJ. Alcohol consumption and alcoholic liver disease: evidence of a threshold level of effects of ethanol. Alcohol Clin Exp Res. 1999;17:1112–1117
  11. Savolainen V, Perola M, Lalu K, Penttila A, Vertanen I, Karhunen PJ. Early perivenular fibrogenesis — precirrhotic lesions among moderate alcohol consumers and chronic alcoholics. J Hepatol. 1995;23:524–531
  12. Westin J, Lagging LM, Spak F, Aires N, Svensson E, Lindh M, et al. Moderate alcohol intake increases fibrosis progression in untreated patients with hepatitis C virus infection. J Viral Hepat. 2002;9:235–241
  13. Jamal MM, Saadi Z, Morgan T. Alcohol and hepatitis C. Dig Dis. 2005;23:285–296
  14. Szabo G, Dolganiuc A. Subversion of plasmacytoid and myeloid dendritic cell functions in chronic HCV infection. Immunobiology. 2005;210:237–247
  15. Fletcher LM, Dixon JL, Purdie DM, Powell LW, Crawford DH. Excess alcohol greatly increases the prevalence of cirrhosis in hereditary hemochromatosis. Gastroenterology. 2002;122:281–289
  16. Naveau S, Giraud V, Borotto E, Aubert A, Capron F, Chaput JC. Excess weight risk factor for alcoholic risk factor. Hepatology. 1997;25:108–111
  17. Raynard B, Balian A, Falik D, Capron F, Bedossa P, Chaput JC, et al. Risk factors of fibrosis in alcohol-induced liver disease. Hepatology. 2002;35:635–638
  18. Arteel G, Marsano L, Mendez C, Bentley F, McClain C. Advances in alcohol liver disease. Best Prac Res Clin Gastroenterol. 2003;17:625–647
  19. MacClain CJ, Cohen DA. Increased tumor necrosis factor production by monocytes in alcoholic hepatitis. Hepatology. 1989;9:349–351
  20. Parlesak A, Schafer C, Schutz T, Bode JC, Bode C. Increased intestinal permeability to macromolecules and endotoxemia in patients with chronic alcohol abuse in different states of alcohol-induced liver disease. J Hepatol. 2000;32:742–747
  21. Stern M, Carter EA, Walker WA. Food proteins and gut mucosal barrier. IV. Effects of acute and chronic ethanol administration on handling and uptake of bovine serum albumin by rat small intestine. Dig Dis Sci. 1986;31:1242–1248
  22. Thompson AD, Heap LC, Ward RJ. Alcohol induced malabsorption in the gastrointestinal tract. In:  Preedy VR,  Watson RR editor. Alcohol and the gastrointestinal tract. Boca Raton (FL): CRC Press; 1996;p. 203–218
  23. Urbaschek R, McCuskey RS, Rudi V, Becker KP, Stickel F, Urbaschek B, et al. Endotoxin, endotoxin-neutralizing-capacity, sCD14, sICAM-1, and cytokines in patients with various degrees of alcoholic liver disease. Alcohol Clin Exp Res. 2001;25:261–268
  24. Nagy LE. Recent insights into the role of the innate immune system in the development of alcoholic liver disease. Exp Biol Med. 2003;228:882–890
  25. Beutler B. TNF, immunity and inflammatory disease: lessons of the past decade. J Investig Med. 1995;43:227–235
  26. Paik YH, Schwabe TF, Bataller R, Russo MP, Jobin C, Brenner DA. Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells. Hepatology. 2003;37:1043–1055
  27. Uetsugi T, Froh M, Arteel G, Bradford BU, Thurman RG. Toll-like receptor 4 is involved in the mechanism of early alcohol-induced liver injury in mice. Hepatology. 2001;34:101–108
  28. Hill DB, Barve S, McClain C. Increased monocyte nuclear factor-kB activation and tumor necrosis factor production in alcoholic patients. J Lab Clin Med. 2000;135:387–395
  29. Mandrekar P, Catalano D, White B, Szabo G. Moderate intake in humans attenuates monocyte inflammatory responses: inhibition of nuclear regulatory factor kappa B and induction of interleukin 10. Alcohol Clin Exp Res. 2006;30:135–139
  30. Szabo G, Chavan S, Mandrekar P, Catalano D. Acute alcohol consumption attenuates IL-8 and MCP-1 induction in response to ex vivo stimulation. J Clin Immunol. 1999;19:67–76
  31. Mandrekar P, Dolganiuc A, Bellerose G, Kodys K, Romics R, Nizamani R, et al. Acute alcohol inhibits the induction of regulatory factor kB activation through CD14/toll-like receptor 4, interleukin-1 and tumor necrosis factor receptors: a common mechanism independent of inhibitory kappa B alpha degradation?. Alcohol Clin Exp Res. 2002;26:1609–1614

PII: S1047-2797(07)00014-2

doi: 10.1016/j.annepidem.2007.01.012

Annals of Epidemiology
Volume 17, Issue 5, Supplement , Pages S49-S54 , May 2007

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