Feasibility of Running Clinics to Collect Biological Specimens in a Nationwide Cohort Study—Adventist Health Study-2
Received 15 August 2006; accepted 24 October 2006. published online 02 April 2007.
Purpose
Collecting biologic and questionnaire data allows analyses that can include both genetic/biomarker and behavioral factors. Therefore, the feasibility of collecting biological specimens from a nationally dispersed cohort (Adventist Health Study-2) was tested.
Methods
We selected 2130 subjects from California, Washington, Texas, and Louisiana to simulate a widely scattered cohort. Clinics were held at local church halls. Nonclinic attendees were invited to mail in their blood samples. The remaining nonparticipants were offered a home visit by a venipuncturist.
Results
Sixty-four percent of nonblack and 38.4% of black invitees attended the clinics. Another 11.3% of nonblack and 5.9% of black subjects from a subsample mailed in their blood samples. A venipuncturist visit collected samples from another 5.3% of nonblack subjects, but hurricanes disrupted this method among blacks. This experience suggests that we could collect biological samples from 81.2% and at least 44.3% of the nonblack and black subjects, respectively.
Conclusions
We have demonstrated the feasibility of collecting biological specimens from black as well as nonblack subjects, with an efficient, cost-effective system, and limited personpower, overcoming many of the complexities imposed by scattered subjects, diversity of culture, as well as cumbersome and varied state legislation governing clinics and clinic personnel.
From the Department of Epidemiology and Biostatistics (J.C., S.F.K., R.Y.M., G.E.F.) and Department of Nutrition (J.S., E.H.), School of Public Health, Loma Linda University, Loma Linda, CA
Address correspondence to: Jacqueline Chan, Department of Epidemiology and Biostatistics School of Public Health, Loma Linda University, Loma Linda, CA 92350. Tel.: 909-558-7246; fax: 909-558-0126.
ABSTRACT