Annals of Epidemiology
Volume 17, Issue 8 , Pages 597-602, August 2007

Risk of Road Traffic Accidents Associated With the Prescription of Drugs: A Registry-Based Cohort Study

  • Anders Engeland, MSc, PhD, PROF.

      Affiliations

    • Corresponding Author InformationAddress correspondence to: Anders Engeland, Division of Epidemiology, Norwegian Institute of Public Health, P.O.Box 4404 Nydalen, N-0403 Oslo, Norway. Tel.: +47-23-40-82-13; fax: +47-23-40-81-46.
    • ,
  • Svetlana Skurtveit, MSc, PhD, PROF.
    • ,
  • Jørg Mørland, MD, PhD, PROF

From the Norwegian Institute of Public Health (A.E., S.S., J.M.); the Department of Public Health and Primary Health Care, University of Bergen (A.E.); the Department of Pharmacy, University of Tromsø (S.S.); and the Department of Pharmacology, University of Oslo (J.M.)

Received 11 October 2006; accepted 3 March 2007. published online 18 June 2007.

Purpose

The aim of this study was to examine the risk of a car driver being involved in a road traffic accident while using prescribed drugs. We used data from population-based registries.

Methods

Information on prescriptions, road traffic accidents, and emigrations/deaths was obtained from population-based registries. The incidence of accidents in the exposed person-time was compared with the incidence in the unexposed person-time, by the standardized incidence ratio (SIR). All Norwegians ages 18–69 between April 2004 and September 2005 (3.1 million), were included in the study.

Results

A total of 13,000 road traffic accidents with personal injuries were registered. The risk of being involved in an accident was somewhat increased in users of prescribed drugs in the first seven days after the date of dispensing (SIR for both sexes combined=1.4; 95% confidence interval: 1.3−1.5). The risk was markedly increased in users of natural opium alkaloids (2.0; 1.7−2.4), benzodiazepine tranquillizers (2.9; 2.5−3.5), and benzodiazepine hypnotics (3.3; 2.1−4.7). Somewhat increased or unchanged SIRs were found for nonsteroidal antiiflammatory drugs (1.5; 1.3-1.9), selective beta-2-adrenoreceptor agonists (i.e., antiasthmatics, 1.5; 1.0−2.1), calcium receptor antagonists (0.9; 0.5−1.5), and penicillin (1.1; 0.8−1.5).

Conclusions

The increased risk of being involved in a road accident as driver while receiving prescribed opiates and benzodiazepines supported the results from other studies.

Key Words: Road Traffic Accidents, Prescribed Drugs, Drivers, Pharmacoepidemiology, Cohort, Population-Based Registries

Selected Abbreviations and Acronyms: NorPD, Norwegian Prescription Database, NRAR, Road Accident Registry, NCPR, Central Population Registry, ATC, Anatomical Therapeutic Chemical, DDD, Defined Daily Doses, NSAIDs, nonsteroidal antiinflammatory drugs, COX, cyclooxygenase, SIR, standardized incidence ratio, 95% CI, 95% confidence interval, CNS, central nervous system

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PII: S1047-2797(07)00143-3

doi:10.1016/j.annepidem.2007.03.009

Annals of Epidemiology
Volume 17, Issue 8 , Pages 597-602, August 2007

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