Annals of Epidemiology
Volume 18, Issue 2 , Pages 119-123 , February 2008

Race in Epidemiology: New Tools, Old Problems

  • Jay S. Kaufman, PhD

      Affiliations

    • Department of Epidemiology, University of North Carolina School of Public Health, Chapel Hill, NC
    • Corresponding Author InformationAddress correspondence to: Jay S. Kaufman, PhD, Department of Epidemiology (CB#7435), University of North Carolina School of Public Health, McGavran-Greenberg Hall, Pittsboro Street, Chapel Hill, NC 27599-7435. Tel.: (919) 966-7435; fax: (919) 966-2089.
    • ,
  • Richard S. Cooper, MD

      Affiliations

    • Department of Preventive Medicine and Epidemiology, Loyola University Medical Loyola University Medical Center, Maywood, IL

References 

  1. van Wyhe J. Phrenology and the origins of Victorian scientific naturalism (science, technology and culture 1700-1945). Burlington (VT): Ashgate Publishing Company; 2004;
  2. Williams DR. Race and health: basic questions, emerging directions. Ann Epidemiol. 1997;7:322–333
  3. Risch N, Burchard E, Ziv E, Tang H. Categorization of humans in biomedical research: genes, race and disease. [comment] Genome Biol. 2002;3:comment2007. Epub 2002 Jul 1
  4. Karter AJ. Commentary: Race, genetics, and disease—in search of a middle ground. Int J Epidemiol. 2003;32:26–28
  5. Bamshad M. Genetic influences on health: does race matter?. JAMA. 2005;294:937–946Erratum in: JAMA. 2005;294:1620
  6. Cooper RS, Psaty BM. Genomics and medicine: distraction, incremental progress, or the dawn of a new age?. Ann Intern Med. 2003;138:576–580
  7. Marks J. Human biodiversity: genes, race, and history. New York: Aldine de Gruyter; 1995;
  8. Rosenberg NA, Pritchard JK, Weber JL, Cann HM, Kidd KK, Zhivotovsky LA, et al. Genetic structure of human populations. Science. 2002;298:2381–2385
  9. Darwin C. The descent of man and selection in relation to sex. London: John Murray; 1871;
  10. Amos W, Manica A. Global genetic positioning: evidence for early human population centers in coastal habitats. Proc Natl Acad Sci U S A. 2006;103:820–824
  11. Rotimi CN. Genetic ancestry tracing and the African identity: a double-edged sword?. Developing World Bioeth. 2003;3:151–158
  12. Tang H, Quertermous T, Rodriguez B, Kardia SL, Zhu X, Brown A, et al. Genetic structure, self-identified race/ethnicity, and confounding in case-control association studies. Am J Hum Genet. 2005;76:268–275
  13. Cooper RS, Kaufman JS. Race and hypertension: science and nescience. Hypertension. 1998;32:813–816
  14. Beckman M. The race for ancestral genetics in clinical trials. J Natl Cancer Inst. 2006;98:1270–1271
  15. Kaufman JS, Cooper RS, McGee DL. Socioeconomic status and health in blacks and whites: the problem of residual confounding and the resiliency of race. Epidemiology. 1997;8:621–628
  16. Kaufman JS, Cooper RS, Hirsch RE, et al. The association of race with frailty. [letter] Ann Epidemiol. 2007;17:157–158
  17. Kistka ZA, Palomar L, Lee KA, Boslaugh SE, Wangler MF, Cole FS, et al. Racial disparity in the frequency of recurrence of preterm birth. Am J Obstet Gynecol. 2007;196:131.e1–6
  18. Palomar L, DeFranco EA, Lee KA, Allsworth JE, Muglia LJ. Paternal race is a risk factor for preterm birth. Am J Obstet Gynecol. 2007;197:152.e1–7
  19. Sabeti PC, Walsh E, Schaffner SF, Varilly P, Fry B, Hutcheson HB, et al. The case for selection at CCR5-Delta32. PLoS Biol. 2005;3:e378
  20. Michael NL, Chang G, Louie LG, Mascola JR, Dondero D, Birx DL, et al. The role of viral phenotype and CCR-5 gene defects in HIV-1 transmission and disease progression. Nat Med. 1997;3:338–340
  21. Gonzalez E, Dhanda R, Bamshad M, Mummidi S, Geevarghese R, Catano G, et al. Global survey of genetic variation in CCR5, RANTES, and MIP-1alpha: impact on the epidemiology of the HIV-1 pandemic. Proc Natl Acad Sci U S A. 2001;98:5199–5204
  22. Tang MX, Stern Y, Marder K, Bell K, Gurland B, Lantigua R, et al. The APOE-epsilon4 allele and the risk of Alzheimer disease among African Americans, whites, and Hispanics. JAMA. 1998;279:751–755
  23. Rothman KJ, Greenland S. Modern epidemiology. 2nd ed.. Philadelphia: Lippincott-Raven; 1998;p. 332–336
  24. Hendrie HC, Murrell J, Gao S, Unverzagt FW, Ogunniyi A, Hall KS. International studies in dementia with particular emphasis on populations of African origin. Alzheimer Dis Assoc Disord. 2006;20(3 Suppl. 2):S42–S46

 This work was supported in part by a Robert Wood Johnson Foundation Investigator Award in Health Policy Research. The views expressed imply no endorsement by the Robert Wood Johnson Foundation. Additional support was received from the National Center on Minority Health and Health Disparities (P60 MD000244). Thu Thi Xuan Nguyen provided editorial assistance.

PII: S1047-2797(07)00439-5

doi: 10.1016/j.annepidem.2007.09.002

Annals of Epidemiology
Volume 18, Issue 2 , Pages 119-123 , February 2008

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