Annals of Epidemiology
Volume 19, Issue 2 , Pages 73-78 , February 2009

Vitamin D Status: Measurement, Interpretation, and Clinical Application

  • Michael F. Holick, PhD, MD

      Affiliations

    • Corresponding Author InformationAddress correspondence to: Michael F. Holick, Boston University School of Medicine, 715 Albany Street, M-1013, Boston, MA 02118. Tel.: 617-638-4545; fax: 617-638-8882.

Received 14 May 2007 ,Accepted 17 December 2007.

References 

  1. Holick MF. Resurrection of vitamin D deficiency and rickets. J Clin Invest. 2006;116:2062–2072
  2. Huldschinsky K. Heilung von Rachitis durch Kunstliche Hohensonne. Deutsche Med. Wochenschr. 1919;45:712–713
  3. Hess AF, Unger LJ. The cure of infantile rickets by sunlight. JAMA. 1921;77:39–41
  4. Holick MF. High prevalence of vitamin D inadequacy and implications for health. Mayo Clin Proc. 2006;81:353–373
  5. Belsey R, Clark MB, Bernat M, Glowacki J, Holick MF, DeLuca HF, et al. The physiologic significance of plasma transport of vitamin D and metabolites. Am J Med. 1974;57:50–56
  6. Haddad JG, Chuy KJ. Competitive protein binding radioassay for 25-hydroxycholecalciferol. J Clin Endocrinol Metab. 1971;33:992–995
  7. Chen TC, Turner AK, Holick MF. Methods for the determination of the circulating concentration of 25-hydroxyvitamin D. J Nutr Biochem. 1990;1:315–319
  8. Brumbaugh PF, Haussler DH, Bursac KM, Haussler MR. Filter assay for 1,25dihydroxyvitamin D3. Utilization of the hormone's target tissue chromatin receptor. Biochemistry. 1974;13:4091–4097
  9. Chen TC, Turner AK, Holick MF. A method for the determination of the circulating concentration of 1,25-dihydroxyvitamin D. J Nutr Biochem. 1990;1:320–327
  10. Chesney RW, Hamstra AJ, DeLuca HF, Horowitz S, Gilbert EF, Hong R, et al. Elevated serum 1,25-dihydroxyvitamin D concentrations in the hypercalcemia of sarcoidosis: Correction by glucocorticoid therapy. J Pediatr. 1981;98:919–922
  11. Horst RL, Hollis BW. Vitamin D assays and their clinical utility. In:  Holick MF editors. Physiology, Molecular Biology, and Clinical Applications. Totowa, NJ: Humana Press Inc.; 1999;p. 239–271
  12. Hollis B. The determination of circulating 25-hydroxyvitamin D: no easy task. J Clin Endocrinol Metab. 2004;89:3149–3151
  13. Jones G. Assay of vitamin D2 and D3 in human plasma by high performance liquid chromatography. Clin Chem. 1978;24:287–298
  14. Holick MF. Variations in 25-hydroxyvitamin D assay results (letter). J Clin Endocrinol Metab. 2005;90:210
  15. Guo T, Taylor RL, Singh RJ, Soldin SJ. Simultaneous determination of 12 steroids by isotope dilution liquid chromatography-photospray ionization tandem mass spectrometry. Clin Chim Acta. 2006;372:76–82
  16. Bouillon R. Vitamin D: From photosynthesis, metabolism, and action to clinical applications. In:  DeGroot LJ,  Jameson JL editor. Endocrinology. Philadelphia: WB Saunders; 2001;p. 1009–1028
  17. Dawson-Hughes B, Heaney RP, Holick MF, Lips P, Meunier PJ, Vieth R. Estimates of optimal vitamin D status (editorial). Osteoporos Int. 2005;16:713–716
  18. Brown EM, Gamba G, Riccardl D, Lombardi M, Butters R, Klfor O, et al. 1 Cloning and characterization of an extracellular Ca2+-sensing receptor from bovine parathyroid. Nature. 1993;366:575–580
  19. Holick MF, Garabedian M. Vitamin D: photobiology, metabolism, mechanism of action, and clinical applications. In:  Favus MJ editors. Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Sixth Edition, Chapter 17. Washington, DC: American Society for Bone and Mineral Research; 2006;p. 129–137
  20. Chapuy MC, Chapuy P, Thomas JL, Hazard MC, Meunier PJ. Biochemical effects of calcium and vitamin D supplementation in elderly, institutionalized, vitamin D-deficient patients. Rev Rhum. 1996;63:135–140
  21. Bakhtiyarova S, Lesnyak O, Kyznesova N, Blankenstein MA, Lips P, et al. Vitamin D status among patients with hip fracture and elderly control subjects in Yekaterinburg, Russia. Osteoporos Int. 2006;17:441–446
  22. Larsen ER, Mosekilde L, Foldspang A. Vitamin D and calcium supplementation prevents osteoporotic fractures in elderly community dwelling residents: a pragmatic population-based 3-year intervention study. J Bone Miner Res. 2004;19:370–378
  23. McKenna MJ, Freany R. Secondary hyperparathyroidism in the elderly: means to defining hypovitaminosis D. Ospeoporos Int. 1998;8(Suppl):S3–S6
  24. Chapuy MC, Preziosi P, Maaner M, Arnaud S, Galan P, Hercberg S, et al. Prevalence of vitamin D insufficiency in an adult normal population. Osteoporosis Int. 1997;7:439–443
  25. Thomas KK, Lloyd-Jones DH, Thadhani RI, et al. Hypovitaminosis D in medical inpatients. N Engl J Med. 1998;338:777–783
  26. Malabanan AO, Turner AK, Holick MF. Severe generalized bone pain and osteoporosis in a premenopausal black female: effect of vitamin D replacement. J Clin Densitometr. 1998;1:201–204
  27. Heaney RP, Dowell MS, Hale CA, Bendich A. Calcium absorption varies within the reference range for serum 25-hydroxyvitamin D. J Am Coll Nutr. 2003;22:142–146
  28. Bischoff-Ferrari HA, Giovannucci E, Willett WC, Dietrich T, Dawson-Hughes B. Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. Am J Clin Nutr. 2006;84:18–28
  29. Vieth R. The Pharmacology of Vitamin D, including fortification strategies. In:  Feldman D,  Pike JW,  Glorieux FH editor. Vitamin D. 2nd ed.. Elsevier Academic Press; 2005;
  30. Vieth R. Why the optimal requirement for vitamin D3 is probably much higher than what is officially recommended for adults. J Steroid Biochem Mol Biol. 2004;89–90:575–579
  31. Koutkia P, Chen TC, Holick MF. Vitamin D intoxication associated with an over-the-counter supplement. N Engl J Med. 2001;345:66–67
  32. Adams JS, Lee G. Gains in bone mineral denisty with resolution of vitamin D intoxication. Ann Intern Med. 1997;127:203–206
  33. Binkley N, Krueger D, Cowgill CS, Plum L, Lake E, Hansen K, et al. Assay variation confounds the diagnosis of hypovitaminosis D: A call for standardization. J Clin Endocrinol Metab. 2004;89:3152–3157

 Editor's note: With this issue, we initiate a symposium on the epidemiology of vitamin D. Our Guest Editor, Dr. Cedric Garland, has overseen the project and will provide an overview and commentary at its completion. The current contribution deal with measurement and clinical interpretation of Vitamin D, and with some aspects of the relationship of Vitamin D and cancer. Subsequent issues will continue the discussion of cancer, with attention to the risks of vitamin D and perspectives on its use for cancer prevention.

 This work was supported in part by NIH grants M01RR00533 and AR36963 and the UV Foundation.

PII: S1047-2797(08)00002-1

doi: 10.1016/j.annepidem.2007.12.001

Annals of Epidemiology
Volume 19, Issue 2 , Pages 73-78 , February 2009

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