Annals of Epidemiology
Volume 18, Issue 7 , Pages 572-578 , July 2008

The Polymorphism of XRCC3 Codon 241 and AFB1-Related Hepatocellular Carcinoma in Guangxi Population, China

  • Xi Dai Long, MD

      Affiliations

    • Department of Pathology, Youjiang Medical College for Nationalities, Baise, Guangxi Zhuang Autonomous Region
    • Corresponding Author InformationAddress correspondence to: Xi Dai Long, MD, Chengxiang Road N0. 98, Baise City, Guangxi Zhuang Autonomous Region, China, 533000. Tel.: +86 776 2849481; fax: +86 776 2849481.
    • ,
  • Yun Ma, MD

      Affiliations

    • Department of Pathology, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region
    • ,
  • De Ying Qu, JS

      Affiliations

    • Department of Pathology, Youjiang Medical College for Nationalities, Baise, Guangxi Zhuang Autonomous Region
    • ,
  • Yun Guang Liu, JS

      Affiliations

    • Department of Medicine, Affiliated Hospital of Youjiang Medical College for Nationalities, Baise, Guangxi Zhuang Autonomous Region
    • ,
  • Zhao Quan Huang, JS

      Affiliations

    • Department of Pathology, Youjiang Medical College for Nationalities, Baise, Guangxi Zhuang Autonomous Region
    • ,
  • Yong Zhi Huang, JS

      Affiliations

    • Department of Pathology, Youjiang Medical College for Nationalities, Baise, Guangxi Zhuang Autonomous Region
    • ,
  • Zhong Hui Lin, MD

      Affiliations

    • Department of Medicine, Zhong Hospital of Xiamen, Xiamen, Fujian Province
    • ,
  • Ni Bo Wei

      Affiliations

    • Department of Clinical Medicine (2004), Youjiang Medical College for Nationalities, Baise, Guangxi Zhuang Autonomous Region
    • ,
  • Shu Chun Zhou

      Affiliations

    • Department of Clinical Medicine, the Second Hospital of Anhua, Hu'nan Province, China

Received 31 October 2007 ,Accepted 1 March 2008.

References 

  1. Hoeijmakers JH. Genome maintenance mechanisms for preventing cancer. Nature. 2001;411:366–374
  2. Wang JS, Groopman JD. DNA damage by mycotoxins. Mutat Res. 1999;424:167–181
  3. Wilson DM, Thompson LH. Life without DNA repair. Proc Natl Acad Sci U S A. 1997;94:12754–12757
  4. Chu G. Double strand break repair. J Biol Chem. 1997;272:24097–24100
  5. Guengerich FP, Johnson WW, Shimada T, Ueng YF, Yamazaki H, Langouet S. Activation and detoxication of aflatoxin B1. Mutat Res. 1998;402:121–128
  6. Long XD, Ma Y, Wei YP, Deng ZL. The polymorphisms of GSTM1, GSTT1, HYL1∗2, and XRCC1, and aflatoxin B1-related hepatocellular carcinoma in Guangxi population, China. Hepatol Res. 2006;36:48–55
  7. Thompson LH, West MG. XRCC1 keeps DNA from getting stranded. Mutat Res. 2000;459:1–18
  8. Pierce AJ, Johnson RD, Thompson LH, Jasin M. XRCC3 promotes homology-directed repair of DNA damage in mammalian cells. Genes Dev. 1999;13:2633–2638
  9. Liu N, Lamerdin JE, Tebbs RS, Schild D, Tucker JD, Shen MR, et al. XRCC2 and XRCC3, new human Rad51-family members, promote chromosome stability and protect against DNA cross-links and other damages. Mol Cell. 1998;1:783–793
  10. Griffin CS, Simpson PJ, Wilson CR, Thacker J. Mammalian recombination-repair genes XRCC2 and XRCC3 promote correct chromosome segregation. Nat Cell Biol. 2000;2:757–761
  11. Matullo G, Palli D, Peluso M, Guarrera S, Carturan S, Celentano E, et al. XRCC1, XRCC3, XPD gene polymorphisms, smoking and (32)P-DNA adducts in a sample of healthy subjects. Carcinogenesis. 2001;22:1437–1445
  12. Au WW, Salama SA, Sierra-Torres CH. Functional characterization of polymorphisms in DNA repair genes using cytogenetic challenge assays. Environ Health Perspect. 2003;111:1843–1850
  13. Zhu G, Duffy DL, Turner DR, Ewen KR, Montgomery GW, Martin NG. Linkage and association analysis of radiation damage repair genes XRCC3 and XRCC5 with nevus density in adolescent twins. Twin Res. 2003;6:315–321
  14. Matullo G, Guarrera S, Carturan S, Peluso M, Malaveille C, Davico L, et al. DNA repair gene polymorphisms, bulky DNA adducts in white blood cells and bladder cancer in a case-control study. Int J Cancer. 2001;92:562–567
  15. Ryk C, Kumar R, Sanyal S, de Verdier PJ, Hemminki K, Larsson P, et al. Influence of polymorphism in DNA repair and defence genes on p53 mutations in bladder tumours. Cancer Lett. 2006;241:142–149
  16. Savas S, Kim DY, Ahmad MF, Shariff M, Ozcelik H. Identifying functional genetic variants in DNA repair pathway using protein conservation analysis. Cancer Epidemiol Biomarkers Prev. 2004;13:801–807
  17. Shen MR, Jones IM, Mohrenweiser H. Nonconservative amino acid substitution variants exist at polymorphic frequency in DNA repair genes in healthy humans. Cancer Res. 1998;58:604–608
  18. Matullo G, Guarrera S, Sacerdote C, Polidoro S, Davico L, Gamberini S, et al. Polymorphisms/haplotypes in DNA repair genes and smoking: A bladder cancer case-control study. Cancer Epidemiol Biomarkers Prev. 2005;14:2569–2578
  19. Smith TR, Miller MS, Lohman K, Lange EM, Case LD, Mohrenweiser HW, et al. Polymorphisms of XRCC1 and XRCC3 genes and susceptibility to breast cancer. Cancer Lett. 2003;190:183–190
  20. Zhang L, Zhang Z, Yan W. Single nucleotide polymorphisms for DNA repair genes in breast cancer patients. Clin Chim Acta. 2005;359:150–155
  21. Lee SA, Lee KM, Park SK, Choi JY, Kim B, Nam J, et al. Genetic polymorphism of XRCC3 Thr241Met and breast cancer risk: Case-control study in Korean women and meta-analysis of 12 studies. Breast Cancer Res Treat. 2007;103:71–76
  22. Hsieh LL, Hsu SW, Chen DS, Santella RM. Immunological detection of aflatoxin B1-DNA adducts formed in vivo. Cancer Res. 1988;48:6328–6331
  23. Stern MC, Umbach DM, Lunn RM, Taylor JA. DNA repair gene XRCC3 codon 241 polymorphism, its interaction with smoking and XRCC1 polymorphisms, and bladder cancer risk. Cancer Epidemiol Biomarkers Prev. 2002;11:939–943
  24. Wacholder S, Chatterjee N, Hartge P. Joint effect of genes and environment distorted by selection biases: Implications for hospital-based case-control studies. Cancer Epidemiol Biomarkers Prev. 2002;11:885–889
  25. Wang JS, Huang T, Su J, et al. Hepatocellular carcinoma and aflatoxin exposure in Zhuqing Village, Fusui County, People's Republic of China. Cancer Epidemiol Biomarkers Prev. 2001;10:143–146
  26. Brenneman MA, Wagener BM, Miller CA, Allen C, Nickoloff JA. XRCC3 controls the fidelity of homologous recombination: Roles for XRCC3 in late stages of recombination. Mol Cell. 2002;10:387–395
  27. Griffin CS. Aneuploidy, centrosome activity and chromosome instability in cells deficient in homologous recombination repair. Mutat Res. 2002;504:149–155
  28. Wood RD. DNA repair in eukaryotes. Annu Rev Biochem. 1996;65:135–167

 Drs. Long and Ma contributed equally to this work.

 This study is supported by the Science Foundation of Youjiang Medical College for Nationalities (NO. 2005 and 2008) and the National Nature & Science Foundation of China (NO. 39860032).

PII: S1047-2797(08)00058-6

doi: 10.1016/j.annepidem.2008.03.003

Annals of Epidemiology
Volume 18, Issue 7 , Pages 572-578 , July 2008

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