Annals of Epidemiology
Volume 19, Issue 6 , Pages 388-395 , June 2009

Occupational Exposure to Metribuzin and the Incidence of Cancer in the Agricultural Health Study

  • John Oliver L. Delancey, MPH

      Affiliations

    • American Cancer Society, Department of Epidemiology and Surveillance Research
    • ,
  • Michael C.R. Alavanja, DrPH

      Affiliations

    • Division of Cancer Epidemiology and Genetics, National Cancer Institute
    • ,
  • Joseph Coble, ScD

      Affiliations

    • Division of Cancer Epidemiology and Genetics, National Cancer Institute
    • ,
  • Aaron Blair, PhD

      Affiliations

    • Division of Cancer Epidemiology and Genetics, National Cancer Institute
    • ,
  • Jane A. Hoppin, ScD

      Affiliations

    • Epidemiology Branch, National Institute of Environmental Health Sciences
    • ,
  • Harland D. Austin, ScD

      Affiliations

    • Emory University Rollins School of Public Health, Department of Epidemiology
    • ,
  • Laura E. Beane Freeman, PhD

      Affiliations

    • Division of Cancer Epidemiology and Genetics, National Cancer Institute
    • Corresponding Author InformationAddress correspondence to: Dr. Laura E. Beane Freeman, National Cancer Institute, Division of Cancer Epidemiology and Genetics, 6120 Executive Blvd., Room 8112, Bethesda, MD 20892-7240. Tel: (301) 451-8793. fax: (301) 402-1819.

Received 12 August 2008 ,Accepted 23 December 2008.

References 

  1. Environmental Protection Agency. Metribuzin, R.E.D. Facts. Washington (DC): Environmental Protection Agency, Office of Prevention, Pesticides, and Toxic Substances; February 1998;(EPA 738-R-97–006)
  2. Environmental Protection Agency. Health Effects Support Document for Metribuzin. Washington (DC): Environmental Protection Agency; 2003;(EPA-733-R-04–001)
  3. International Programme on Chemical Safety. The WHO Recommended Classification of Pesticides by Hazard. Geneva: World Health Organization; 2002;Available at http://www.who.int/ipcs/publications/en/pesticides_hazard.pdfAccessed April 15, 2007
  4. Environmental Protection Agency. Integrated Risk Information System (IRIS): Metribuzin. Washington (DC): Environmental Protection Agency; December 1993;Available at http://www.epa.gov/iris/subst/0075.htmAccessed April 15, 2007
  5. Kaya B, Yanikoglu A, Creus A, Marcos R. Genotoxicity testing of five herbicides in the Drosophila wing spot test. Mutat Res. 2000;465:44–84
  6. Flores-Maya S, Gómez-Arroyo S, Calderón-Segura ME, Villalobos-Pietrini R, Waliszewski SM, de la Cruz LG. Promutagen activation of triazine herbicides metribuzin and ametryn through Vicia faba metabolism inducing sister chromatid exchanges in human lymphocytes in vitro and in V. faba root tip meristems. Toxicol In Vitro. 2005;19:243–251
  7. Moriya M, Ohta T, Watanabe K, Miyazawa T, Kato K, Shirasu Y. Further mutagenicity studies on pesticides in bacterial reversion assay systems. Mutat Res. 1983;116:185–216
  8. Xu HH, Schurr KM. Genotoxicity of 22 pesticides in the microtitration SOS chromotest. Toxicol Assessment. 1990;5:1–14
  9. Venkat JA, Shami S, Davis K, Nayak M, Plimmer JR, Pfeil R, et al. Relative genotoxic activities of pesticides evaluated by a modified SOS microplate assay. Environ Mol Mutagen. 1995;25:67–76
  10. Clements C, Ralph S, Petras M. Genotoxicity of select herbicides in Rana catesbeiana tadpoles using the alkaline single-cell gell DNA electrophoresis (comet) assay. Environ Mol Mutagen. 1997;29:277–288
  11. Shah RG, Lagueux J, Kapur S, Levallois P, Ayotte P, Tremblay M, et al. Determination of genotoxicity of the metabolites of the pesticides Guthion, Sencor, Lorox, Reglone, Daconil, and Admire by 32P-postlabeling. Mol Cell Biochem. 1997;169:177–184
  12. Bleeke MS, Smith MD, Casida JE. Metabolism and toxicity of metribuzin in mouse liver. Pesticide Biochemistry and Physiology. 1985;23:123–130
  13. De Roos AJ, Zahm SH, Cantor KP, Weisenburger DD, Holmes FF, Burmeister LF, et al. Integrative assessment of multiple pesticides as factors for non-Hodgkin's lymphoma among men. Occup Environ Med. 2003;60:e11
  14. Lee WJ, Colt JS, Heineman EF, McComb R, Weisenburger DD, Lijinsky W, et al. Agricultural pesticide use and risk of glioma in Nebraska, United States. Occup Environ Med. 2005;62:786–792
  15. Alavanja MC, Sandler DP, McMaster SB, Zahm SH, McDonnell CJ, Lynch CF, et al. The Agricultural Health Study. Environ Health Perspect. 1996;104:362–369
  16. Tarone RE, Alavanja MC, Zahm SH, Lubin JH, Sandler DP, McMaster SB, et al. The Agricultural Health Study: factors affecting completion and return of self-administered questionnaires in a large prospective cohort study of pesticide applicators. Am J Ind Med. 1997;31:233–242
  17. Dosemeci M, Alavanja MC, Rowland AS, Mage D, Zahm SH, Rothman N, et al. A quantitative approach for estimating exposure to pesticides in the Agricultural Health Study. Ann Occup Hyg. 2002;46:245–260
  18. Coble J, Arbuckle T, Lee W, Alavanja M, Dosemeci M. The validation of a pesticide exposure algorithm using biological monitoring results. J Occup Environ Hyg. 2005;2:194–201
  19. Rakitsky VN, Koblyakov VA, Turusov VS. Nongenotoxic (epigenetic) carcinogens: pesticides as an example. A critical review. Teratog Carcinog Mutagen. 2000;20:229–240
  20. Coble J, Hoppin JA, Engel L, Elci OC, Dosemeci M, Lynch CF, et al. Prevalence of exposure to solvents, metals, grain dust, and other hazards among farmers in the Agricultural Health Study. J Expo Anal Environ Epidemiol. 2002;12:418–426

PII: S1047-2797(09)00040-4

doi: 10.1016/j.annepidem.2008.12.018

Annals of Epidemiology
Volume 19, Issue 6 , Pages 388-395 , June 2009

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