Annals of Epidemiology
Volume 19, Issue 10 , Pages 740-745, October 2009

HTRA1 Promoter Polymorphism and Risk of Age-Related Macular Degeneration: A Meta-Analysis

  • Na-Ping Tang, MD

      Affiliations

    • National Shanghai Center for New Drug Safety Evaluation and Research, Shanghai Institute of Pharmaceutical Industry, Shanghai, China
    • Corresponding Author InformationAddress correspondence to: Na-Ping Tang, MD, National Shanghai Center for New Drug Safety Evaluation and Research, Shanghai institute of pharmaceutical industry, 199 Guoshoujing Road, Zhangjiang Hi-Tech Park, Pudong, Shanghai 201203, China. Tel.: +86 21 50800333; fax: +86 21 50801259.
    • ,
  • Bo Zhou, MD

      Affiliations

    • Jiangsu Center for Safety Evaluation of Drugs, Nanjing Medical University, Nanjing, Jiangsu Province, China
    • ,
  • Bin Wang, PhD

      Affiliations

    • Department of Pharmacology, Nanjing Medical University, Nanjing, Jiangsu Province, China
    • ,
  • Rong-Bin Yu, PhD

      Affiliations

    • Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu Province, China

Received 19 October 2008; accepted 2 March 2009. published online 20 April 2009.

Purpose

To clarify the role of human high-temperature requirement A-1 (HTRA1) gene promoter polymorphism (-512G>A) in age-related macular degeneration (AMD).

Methods

Relevant studies were identified by searching PubMed and EMBASE database. A logistic regression analysis proposed for molecular association studies was carried out to estimate the genetic effect and the possible genetic model of action.

Results

Fourteen case-control studies were included in this meta-analysis. There was strong evidence for an association between HTRA1 -512G>A polymorphism and AMD (p < 0.001). The genetic model test indicated that the genetic model was most likely to be co-dominant. Overall, our meta-analysis showed that AA and GA genotypes were associated with increased risk of AMD (AA vs. GG: odds ratio1 [OR1] = 7.46; 95% confidence interval [CI] = 6.16-9.04; GA vs. GG: OR2 = 2.27, 95% CI = 2.02–2.55). In stratified analysis by ethnicity and age, the genetic effect seemed to be stronger in Caucasians and subjects ≥73 years of age than in Asians and subjects <73 years of age. When subgroup analysis was conducted by AMD type, significant association was noted for wet AMD but not for dry AMD.

Conclusions

This meta-analysis summarizes the strong evidence for an association between HTRA1 -512G>A polymorphism and AMD and indicates a co-dominant model of action.

key Words: HTRA1 Polymorphism, Age-Related Macular Degeneration, Meta-Analysis

Selected Abbreviations and Acronyms: AMD, age-related macular degeneration, CFH, complement factor H, CI, confidence interval, HTRA1, human high-temperature requirement A-1, HWE, Hardy-Weinberg equilibrium, OR, odds ratio, PLEKHA1, pleckstrin homology domain, containing family A, member 1, SNP, single nucleotide polymorphism

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

PII: S1047-2797(09)00073-8

doi:10.1016/j.annepidem.2009.03.002

Annals of Epidemiology
Volume 19, Issue 10 , Pages 740-745, October 2009

Article Tools

* Image Usage & Resolution