Sibling History of Myocardial Infarction or Stroke and Risk of Cardiovascular Disease in the Elderly: The Cardiovascular Health Study
Received 27 January 2009; accepted 16 July 2009.
Purpose
To assess the relationship between sibling history of myocardial infarction (MI) or stroke with cardiovascular disease (CVD) and risk factors in older adults.
Methods
Prospective cohort study of 5,888 older adults participating in the Cardiovascular Health Study (CHS). History of MI and stroke in siblings was obtained by self-report. Participants with positive sibling histories were compared to those with negative histories to determine if prevalent or incident disease (coronary heart disease [CHD], MI, stroke, angina), subclinical CVD (carotid wall thickness, left ventricular mass, hypertension, diabetes, ankle-brachial index), CVD risk factors differed between groups.
Results
More than 91% (n=5,383) of CHS participants reported at least one sibling. Sibling history of MI was associated with increased disease prevalence (CHD, MI, angina) and incidence (CHD, angina). Sibling history of stroke was associated with increased disease prevalence (CHD, angina). Sibling history of either MI or stroke was associated with increased disease prevalence and incidence for CHD, MI and angina, more subclinical disease, and a higher CVD risk profile.
Conclusions
Sibling history of MI and stroke were markers of higher CVD risk status even in older adults. Of clinical importance, participants with positive sibling history have numerous risk factors amenable to intervention.
aDepartment of Biostatistics, University of Washington, Seattle
bDepartment of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC
cNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD
dDivision of Cardiology, St. John Hospital and Medical Center, Detroit, MI
eDepartment of Radiology, Tufts University, Boston, MA
Address correspondence to: N. David Yanez, PhD, Department of Biostatistics, Box 357232, 1959 NE Pacific St, University of Washington, Seattle, WA 98195. Tel: (206) 543-1044. Fax: (206) 543-3286.
A list of participating institutions and principal staff of the CHS Collaborative Research Group can be accessed through the website given at the end of the article.
ABSTRACT