Annals of Epidemiology
Volume 20, Issue 3 , Pages 210-216 , March 2010

Body Composition Among HIV-Seropositive and HIV-Seronegative Adult Patients with Pulmonary Tuberculosis in Uganda

  • Ezekiel Mupere, MBChB, MMED, MS

      Affiliations

    • Department of Paediatrics and Child Health, School of Medicine, Makerere University, Kampala, Uganda
    • Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH
  • ,
  • Sarah Zalwango, MBChB

      Affiliations

    • Uganda-Case Western Reserve University Research Collaboration, Kampala
  • ,
  • Allan Chiunda, MPH

      Affiliations

    • Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH
  • ,
  • Alphonse Okwera, MBChB

      Affiliations

    • Uganda-Case Western Reserve University Research Collaboration, Kampala
  • ,
  • Roy Mugerwa, MBChB, MMED

      Affiliations

    • Department of Internal Medicine, School of Medicine, Makerere University, Kampala, Uganda
    • Uganda-Case Western Reserve University Research Collaboration, Kampala
  • ,
  • Christopher Whalen, MD, MS

      Affiliations

    • Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH
    • Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia
    • Corresponding Author InformationAddress correspondence to: Dr. Christopher C. Whalen, Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Coverdell Center for Biomedical and Health Sciences, Athens, GA 30802. Tel: (706) 227-4736. Fax: (706) 583-0695.

Received 19 May 2009 ,Accepted 21 November 2009.

References 

  1. Rubin SA. Tuberculosis. Captain of all these men of death. Radiol Clin North Am. 1995;33:619–639
  2. Schwenk A, Macallan DC. Tuberculosis, malnutrition and wasting. Curr Opin Clin Nutr Metab Care. 2000;3:285–291
  3. World Health Organization. Global Tuberculosis Control: Surveillance, Planning, Financing. Geneva: WHO Report 2004; 2004;
  4. van Lettow M, Fawzi WW, Semba RD. Triple trouble: the role of malnutrition in tuberculosis and human immunodeficiency virus co-infection. Nutr Rev. 2003;61:81–90
  5. Lucas SB, De Cock KM, Hounnou A, Peacock C, Diomande M, Honde M, et al. Contribution of tuberculosis to slim disease in Africa. BMJ. 1994;308:1531–1533
  6. Paton NI, Castello-Branco LR, Jennings G, Ortigao-de-Sampaio MB, Elia M, Costa S, et al. Impact of tuberculosis on the body composition of HIV-infected men in Brazil. J Acquir Immune Defic Syndr Hum Retrovirol. 1999;20:265–271
  7. Paton NI, Ng YM, Chee CB, Persaud C, Jackson AA. Effects of tuberculosis and HIV infection on whole-body protein metabolism during feeding, measured by the [15N]glycine method. Am J Clin Nutr. 2003;78:319–325
  8. Macallan DC, McNurlan MA, Kurpad AV, de Souza G, Shetty PS, Calder AG, et al. Whole body protein metabolism in human pulmonary tuberculosis and undernutrition: evidence for anabolic block in tuberculosis. Clin Sci (Lond). 1998;94:321–331
  9. Zachariah R, Spielmann MP, Harries AD, Salaniponi FM. Moderate to severe malnutrition in patients with tuberculosis is a risk factor associated with early death. Trans R Soc Trop Med Hyg. 2002;96:291–294
  10. Shah S, Whalen C, Kotler DP, Mayanja H, Namale A, Melikian G, et al. Severity of human immunodeficiency virus infection is associated with decreased phase angle, fat mass and body cell mass in adults with pulmonary tuberculosis infection in Uganda. J Nutr. 2001;131:2843–2847
  11. Kennedy N, Ramsay A, Uiso L, Gutmann J, Ngowi FI, Gillespie SH. Nutritional status and weight gain in patients with pulmonary tuberculosis in Tanzania. Trans R Soc Trop Med Hyg. 1996;90:162–166
  12. Van Lettow M, Kumwenda JJ, Harries AD, Whalen CC, Taha TE, Kumwenda N, et al. Malnutrition and the severity of lung disease in adults with pulmonary tuberculosis in Malawi. Int J Tuberc Lung Dis. 2004;8:211–217
  13. Whalen CC, Nsubuga P, Okwera A, Johnson JL, Hom DL, Michael NL, et al. Impact of pulmonary tuberculosis on survival of HIV-infected adults: a prospective epidemiologic study in Uganda. AIDS. 2000;14:1219–1228
  14. Niyongabo T, Henzel D, Idi M, Nimubona S, Gikoro E, Melchior JC, et al. Tuberculosis, human immunodeficiency virus infection, and malnutrition in Burundi. Nutrition. 1999;15:289–293
  15. Niyongabo T, Mlika-Cabanne N, Barihuta T, Henzel D, Aubry P, Larauze B. Malnutrition, tuberculosis and HIV infection in Burundi. AIDS. 1994;8:851–852
  16. Durnin JV, Womersley J. Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 years. Br J Nutr. 1974;32:77–97
  17. Villamor E, Saathoff E, Mugusi F, Bosch RJ, Urassa W, Fawzi WW. Wasting and body composition of adults with pulmonary tuberculosis in relation to HIV-1 coinfection, socioeconomic status, and severity of tuberculosis. Eur J Clin Nutr. 2006;60:163–171
  18. Kyle UG, Bosaeus I, De Lorenzo AD, Deurenberg P, Elia M, Manuel Gomez J, et al. Bioelectrical impedance analysis–part II: Utilization in clinical practice. Clin Nutr. 2004;23:1430–1453
  19. Kyle UG, Piccoli A, Pichard C. Body composition measurements: interpretation finally made easy for clinical use. Curr Opin Clin Nutr Metab Care. 2003;6:387–393
  20. Kotler DP, Burastero S, Wang J, Pierson RN. Prediction of body cell mass, fat-free mass, and total body water with bioelectrical impedance analysis: effects of race, sex, and disease. Am J Clin Nutr. 1996;64:489S–497S
  21. Sun SS, Chumlea WC, Heymsfield SB, Lukaski HC, Schoeller D, Friedl K, et al. Development of bioelectrical impedance analysis prediction equations for body composition with the use of a multicomponent model for use in epidemiologic surveys. Am J Clin Nutr. 2003;77:331–340
  22. Roubenoff R. Applications of bioelectrical impedance analysis for body composition to epidemiologic studies. Am J Clin Nutr. 1996;64:459S–462S
  23. Jackson AS, Pollock ML, Graves JE, Mahar MT. Reliability and validity of bioelectrical impedance in determining body composition. J Appl Physiol. 1988;64:529–534
  24. Ott M, Fischer H, Polat H, Helm EB, Frenz M, Caspary WF, et al. Bioelectrical impedance analysis as a predictor of survival in patients with human immunodeficiency virus infection. J Acquir Immune Defic Syndr Hum Retrovirol. 1995;9:20–25
  25. Andres R, Elahi D, Tobin JD, Muller DC, Brant L. Impact of age on weight goals. Ann Intern Med. 1985;103:1030–1033
  26. Lucas SB, Diomande M, Hounnou A, Beaumel A, Giordano C, Kadio A, et al. HIV-associated lymphoma in Africa: an autopsy study in Cote d'Ivoire. Int J Cancer. 1994;59:20–24
  27. Macallan DC, Noble C, Baldwin C, Foskett M, McManus T, Griffin GE. Prospective analysis of patterns of weight change in stage IV human immunodeficiency virus infection. Am J Clin Nutr. 1993;58:417–424
  28. Paton NI, Ng YM. Body composition studies in patients with wasting associated with tuberculosis. Nutrition. 2006;22:245–251
  29. Swaminathan S, Padmapriyadarsini C, Sukumar B, Iliayas S, Kumar SR, Triveni C, et al. Nutritional status of persons with HIV infection, persons with HIV infection and tuberculosis, and HIV-negative individuals from southern India. Clin Infect Dis. 2008;46:946–949
  30. Swanson B, Hershow RC, Sha BE, Benson CA, Cohen M, Gunfeld C. Body composition in HIV-infected women. Nutrition. 2000;16:1064–1068
  31. Heymsfields SB. Nutritional Assessment by Clinical and Biochemical Methods. Modern Nutrition in Health and Disease. 7th ed.. Philadelphia: Williams & Wilkins; 1988;
  32. Suttmann U, Ockenga J, Selberg O, Hoogestraat L, Deicher H, Muller MJ. Incidence and prognostic value of malnutrition and wasting in human immunodeficiency virus-infected outpatients. J Acquir Immune Defic Syndr Hum Retrovirol. 1995;8:239–246
  33. Kotler DP, Tierney AR, Wang J, Pierson RN. Magnitude of body-cell-mass depletion and the timing of death from wasting in AIDS. Am J Clin Nutr. 1989;50:444–447
  34. Keys A. The biology of human starvation. Minneapolis: University of Minnesota Press; 1950;
  35. Morley JE, Thomas DR, Wilson MM. Cachexia: pathophysiology and clinical relevance. Am J Clin Nutr. 2006;83:735–743
  36. Forbes GB. Lean body mass-body fat interrelationships in humans. Nutr Rev. 1987;45:225–231
  37. Forbes GB. Body fat content influences the body composition response to nutrition and exercise. Ann N Y Acad Sci. 2000;904:359–365
  38. Argiles JM, Lopez-Soriano J, Busquets S, Lopez-Soriano FJ. Journey from cachexia to obesity by TNF. FASEB J. 1997;11:743–751
  39. Thomas DR. Distinguishing starvation from cachexia. Clin Geriatr Med. 2002;18:883–891
  40. Yeh SS, Blackwood K, Schuster MW. The cytokine basis of cachexia and its treatment: are they ready for prime time?. J Am Med Dir Assoc. 2008;9:219–236

PII: S1047-2797(09)00357-3

doi: 10.1016/j.annepidem.2009.11.001

Annals of Epidemiology
Volume 20, Issue 3 , Pages 210-216 , March 2010