Annals of Epidemiology
Volume 20, Issue 3 , Pages 217-222 , March 2010

Subsequent Autoimmune or Related Disease in Asthma Patients: Clustering of Diseases or Medical Care?

  • Kari Hemminki, MD, PhD

      Affiliations

    • Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
    • Center for Family and Community Medicine, Karolinska Institute, Huddinge, Sweden
    • Center for Primary Health Care Research, Lund University, Malmö, Sweden
    • Corresponding Author InformationAddress correspondence to: K. Hemminki, DKFZ, Im Neuenheimer Feld 580, D-69120 Heidelberg, Germany. Tel: 49-6221-421800; Fax 49-6221-421810.
    • ,
  • Xinjun Li, MD, PhD

      Affiliations

    • Center for Primary Health Care Research, Lund University, Malmö, Sweden
    • ,
  • Jan Sundquist, MD, PhD

      Affiliations

    • Center for Primary Health Care Research, Lund University, Malmö, Sweden
    • Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, CA
    • ,
  • Kristina Sundquist, MD, PhD

      Affiliations

    • Center for Family and Community Medicine, Karolinska Institute, Huddinge, Sweden
    • Center for Primary Health Care Research, Lund University, Malmö, Sweden

Received 7 August 2009 ,Accepted 25 November 2009.

References 

  1. McGeady S. Immunocompetence and allergy. Pediatrics. 2006;113:1107–1113
  2. Holgate ST, Polosa R. The mechanisms, diagnosis, and management of severe asthma in adults. Lancet. 2006;368:780–793
  3. Yeatts K, Sly P, Shore S, Weiss S, Martinez F, Geller A, et al. A brief targeted review of susceptibility factors, environmental exposures, asthma incidence, and recommendations for future asthma incidence research. Environ Health Perspect. 2006;114:634–640
  4. Akkoc T, de Koning PJ, Ruckert B, Barlan I, Akdis M, Akdis CA. Increased activation-induced cell death of high IFN-gamma-producing T(H)1 cells as a mechanism of T(H)2 predominance in atopic diseases. J Allergy Clin Immunol. 2008;121:652–658 e1
  5. Rabin RL, Levinson AI. The nexus between atopic disease and autoimmunity: A review of the epidemiological and mechanistic literature. Clin Exp Immunol. 2008;153:19–30
  6. Kero J, Gissler M, Hemminki E, Isolauri E. Could TH1 and TH2 diseases coexist? Evaluation of asthma incidence in children with coeliac disease, type 1 diabetes, or rheumatoid arthritis: A register study. J Allergy Clin Immunol. 2001;108:781–783
  7. Simpson CR, Anderson WJ, Helms PJ, Taylor MW, Watson L, Prescott GJ, et al. Coincidence of immune-mediated diseases driven by Th1 and Th2 subsets suggests a common aetiology. A population-based study using computerized general practice data. Clin Exp Allergy. 2002;32:37–42
  8. Sheikh A, Smeeth L, Hubbard R. There is no evidence of an inverse relationship between TH2-mediated atopy and TH1-mediated autoimmune disorders: Lack of support for the hygiene hypothesis. J Allergy Clin Immunol. 2003;111:131–135
  9. Schreiber S, Rosenstiel P, Albrecht M, Hampe J, Krawczak M. Genetics of Crohn disease, an archetypal inflammatory barrier disease. Nat Rev Genet. 2005;6:376–388
  10. The Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature. 2007;447:661–683
  11. Vercelli D. Discovering susceptibility genes for asthma and allergy. Nat Rev Immunol. 2008;8:169–182
  12. Tirosh A, Mandel D, Mimouni FB, Zimlichman E, Shochat T, Kochba I. Autoimmune diseases in asthma. Ann Intern Med. 2006;144:877–883
  13. Gill G, Williams G. Brittle Addison's disease: A new variant on a familial theme. Postgrad Med J. 2000;76:166–167
  14. Ayres JG, Jyothish D, Ninan T. Brittle asthma. Paediatr Respir Rev. 2004;5:40–44
  15. Hemminki K, Li X, Sundquist J, Sundquist K. Familial associations of rheumatoid arthritis with autoimmune disorders and related conditions. Arthritis Rheum. 2009;60:661–668
  16. Hemminki K, Shu X, Li X, Ji J, Sundquist K, Sundquist J. Familial risks for hospitalized Graves' disease and goiter. Eur J Endocrinol. 2009;161:623–629
  17. Elfstrom P, Montgomery SM, Kampe O, Ekbom A, Ludvigsson JF. Risk of thyroid disease in individuals with celiac disease. J Clin Endocrinol Metab. 2008;93:3915–3921
  18. Hemminki K, Li X, Sundquist J, Sundquist K. Familial association between type 1 diabetes and other autoimmune and related diseases. Diabetologia. 2009;52:1820–1828
  19. Kumar V, Cotran R, Robbins S. Basic Pathology. Philadelphia: W.B. Saunders; 1997;
  20. Abril A, Calamia KT, Cohen MD. The Churg Strauss syndrome (allergic granulomatous angiitis): review and update. Semin Arthritis Rheum. 2003 Oct;33:106–114
  21. Sekiuchi M, Nakabayashi K, Marumo T, Arimura Y, Nagasawa T, Yamada A, et al. Concurrent occurrence of allergic granulomatous angiitis and temporal arteritis: a case report and review of the literature. Mod Rheumatol. 2005;15:126–129
  22. Saraclar Y, Turktas I, Adalioglu G, Tuncer A. Bronchial asthma with Addison's disease. Respiration. 1993;60:241–242

 This work was supported by the National Institutes of Health (Grant No. R01-H271084-1), the Swedish Research Council (Grant No. K2001-27X-11651-06C), and the Swedish Council for Working Life and Social Research (Grant No. 2001-2373).

PII: S1047-2797(09)00363-9

doi: 10.1016/j.annepidem.2009.11.007

Annals of Epidemiology
Volume 20, Issue 3 , Pages 217-222 , March 2010

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