Annals of Epidemiology
Volume 22, Issue 2 , Pages 104-111 , February 2012

Racial Discrimination, Mood Disorders, and Cardiovascular Disease Among Black Americans

  • David H. Chae, ScD, MA

      Affiliations

    • Rollins School of Public Health, Emory University, Atlanta, GA
    • Corresponding Author InformationAddress correspondence to: David H. Chae, ScD, MA, Emory University, Rollins School of Public Health, Department of Behavioral Sciences and Health Education, 1518 Clifton Road NE, Room 512, Atlanta, GA 30309. Tel.: +1-404-727-8226; Fax: +1-404-727-1369.
    • ,
  • Amani M. Nuru-Jeter, PhD

      Affiliations

    • School of Public Health, University of California, Berkeley, CA
    • ,
  • Karen D. Lincoln, PhD

      Affiliations

    • School of Social Work, University of Southern California, Los Angeles, CA
    • ,
  • Kimberly R. Jacob Arriola, PhD, MPH

      Affiliations

    • Rollins School of Public Health, Emory University, Atlanta, GA

Received 9 June 2011 ,Accepted 14 October 2011.

References 

  1. National Center for Health Statistics. Health, United States, 2008: With Special Feature on the Health of Young Adults. Hyattsville, MD: National Center for Health Statistics; 2009;
  2. Centers for Disease Control and Prevention. Racial/ethnic and socioeconomic disparities in multiple risk factors for heart disease and stroke—United States, 2003. MMWR. 2006;54:113–117
  3. Kurian AK, Cardarelli KM. Racial and ethnic differences in cardiovascular disease risk factors: A systematic review. Ethn Dis. 2007;17:143–152
  4. Mensah GA, Mokdad AH, Ford ES, Greenlund KJ, Croft JB. State of disparities in cardiovascular health in the United States. Circulation. 2005;111:1233–1241
  5. Sher Y, Lolak S, Maldonado JR. The impact of depression in heart disease. Curr Psychiatry Rep. 2010;12:255–264
  6. Kubzansky LD, Kawachi I. Going to the heart of the matter: Do negative emotions cause coronary heart disease?. J Psychom Res. 2000;48:323–337
  7. Joynt KE, Whellan DJ, O’Connor CM. Depression and cardiovascular disease: Mechanisms of interaction. Biol Psychiatry. 2003;54:248–261
  8. Rutledge T, Linke SE, Krantz DS, Johnson BD, Bittner V, Eastwood JA, et al. Comorbid depression and anxiety symptoms as predictors of cardiovascular events: Results from the NHLBI-sponsored Women’s Ischemia Syndrome Evaluation (WISE) study. Psychom Med. 2009;71:958–964
  9. Glassman AH, Bigger JR, Gaffney M. Psychiatric characteristics associated with long-term mortality among 361 patients having an acute coronary syndrome and major depression: Seven-year follow-up of SADHART participants. Arch Gen Psychiatry. 2009;66:1022–1029
  10. Carney RM, Freedland KE, Steinmeyer B, Blumenthal JA, Berkman LF, Watkins LL, et al. Depression and five year survival following acute myocardial infarction: A prospective study. J Affect Disord. 2008;109:133–138
  11. Holley C, Murrell SA, Mast BT. Psychosocial and vascular risk factors for depression in the elderly. Am J Geriatr Psychiatry. 2006;14:84–90
  12. Glassman , Gaffney M, Shapiro PA, Swenson JR. Onset of major depression associated with acute coronary syndromes: Relationship of onset, major depressive disorder history, and episode severity to sertraline benefit. Arch Gen Psychiatry. 2006;63:283–288
  13. Freedland KE, Carney RM, Skala JA. Depression and smoking in coronary heart disease. Psychosom Med. 2005;67:S42–S46
  14. Gehi A, Haas D, Pipkin S, Whooley MA. Depression and medication adherence in outpatients with coronary heart disease: Findings from the Heart and Soul Study. Arch Intern Med. 2005;165:2508–2513
  15. Rugulies R. Depression as a predictor for coronary heart disease: A review and meta-analysis. Am J Prev Med. 2002;23:51–61
  16. Lett H, Blumental J, Babyak M, Sherwood A, Strauman T, Robins C, et al. Depression as a risk factor for coronary artery disease: Evidence, mechanisms, and treatment. Psychosom Med. 2004;66:305–315
  17. Joynt KE, Whellan DJ, O’Connor CM. Why is depression bad for the failing heart? A review of the mechanistic relationship between depression and heart failure. J Cardiac Failure. 2004;10:258–271
  18. Raison CL, Miller AH. When not enough is too much: the role of insufficient glucocorticoid signaling in the pathophysiology of stress-related disorders. Am J Psychiatry. 2003;160:1554–1565
  19. Vaccarino V, Johnson BD, Sheps DS, Reis SE, Kelsey SF, Bittner V, et al. Depression, inflammation, and incident cardiovascular disease in women with suspected coronary ischemia. J Am Coll Cardiol. 2007;50:2044–2050
  20. Gallagher P, Reid KS, Ferrier IN. Neuropsychological functioning in heath and mood disorder: modulation by glucocorticoids and their receptors. Psychoneuroendocrinology. 2009;34:S196–S207
  21. Girod JP, Brotman DJ. Does altered glucocorticoid homeostasis increase cardiovascular risk?. Cardiovasc Res. 2004;64:217–226
  22. Vaccarino V, McClure C, Johnson BD, Sheps DS, Bittner V, Rutledge T, et al. Depression, the metabolic syndrome and cardiovascular risk. Psychom Med. 2008;70:40–48
  23. Arborelius L, Owens MJ, Plotsky PM, Nemeroff CB. The role of corticotropin-releasing factor in depression and anxiety disorders. J Endocrinol. 1999;160:1–12
  24. Ehlert U, Gaab J, Heinrichs M. Psychoneuroendocrinological contributions to the etiology of depression, posttraumatic stress disorder, and stress-related bodily disorders: The role of the hypothalamus-pituitary-adrenal axis. Biol Psychol. 2001;57:141–152
  25. Ford DE, Erlinger TP. Depression and C-reactive protein in US adults: Data from the Third National Health and Nutrition Examination Survey. Arch Intern Med. 2004;164:1010–1014
  26. Stewart JC, Rand KL, Muldoon MF, Kamarck TW. A prospective evaluation of the directionality of the depression-inflammation relationship. Brain Behav Immun. 2009;23:936–944
  27. Danner M, Kasl SV, Abramson JL, Vaccarino V. Association between depression and elevated C-reactive protein. Psychosom Med. 2003;65:347–356
  28. Panagiotakos DB, Pitsavos C, Chrysohoou C, Tsetsekou E, Papageorgiou C, Christodoulou G, et al. Inflammation, coagulation and depressive symptomatology in cardiovascular disease-free people; the ATTICA study. Eur Heart J. 2004;25:492–499
  29. Ranjit N, Diez-Roux AV, Shea S, Cushman M, Seeman T, Jackson SA, et al. Psychosocial factors and inflammation in the Multi-Ethnic Study of Atherosclerosis. Arch Intern Med. 2007;167:174–181
  30. Williams DR, Neighbors H. Racism, discrimination and hypertension: Evidence and needed research. Ethn Dis. 2001;11:800–816
  31. Harrell JP, Hall S, Taliaferro J. Physiological responses to racism and discrimination: An assessment of the evidence. Am J Public Health. 2003;93:243–248
  32. Brondolo E, Rieppi R, Kelly KP, Gerin W. Perceived racism and blood pressure: A review of the literature and conceptual and methodological critique. Ann Behav Med. 2003;25:55–65
  33. Williams DR, Neighbors HW, Jackson JS. Racial/ethnic discrimination and health: Findings from community studies. Am J Public Health. 2003;93:200–208
  34. Clark R, Anderson NB, Clar VR, Williams DR. Racism as a stressor for African Americans—A biopsychosocial model. Am Psychol. 1999;54:805–816
  35. Geronimus AT, Hicken M, Keene D, Bound J. “Weathering” and age patterns of allostatic load scores among Blacks and Whites in the United States. Am J Public Health. 2006;96:826–833
  36. Geronimus AT, Hicken MT, Pearson JA, Seashols SJ, Brown KL, Cruz TD. Do US black women experience stress-related accelerated biological aging?. Hum Nat. 2010;21:19–38
  37. Guyll M, Matthews KA, Bromberger JT. Discrimination and unfair treatment: relationship to cardiovascular reactivity among African American and European American women. Health Psychol. 2001;20:315–325
  38. Merritt MM, Bennett GG, Williams RB, Edwards CL, Sollers JJ. Perceived racism and cardiovascular reactivity and recovery to personally relevant stress. Health Psychol. 2006;364–369
  39. Cozier Y, Palmer JR, Horton NJ, Fredman L, Wise LA, Rosenberg L. Racial discrimination and the incidence of hypertension in US Black women. Ann Epidemiol. 2006;16:681–687
  40. Brondolo E, Libby DJ, Denton EG, et al. Racism and ambulatory blood pressure in a community sample. Psychom Med. 2008;70:49–56
  41. Davis SK, Liu Y, Quarells RC, Din-Dzietharn R. Stress-related racial discrimination and hypertension likelihood in a population-based sample of African Americans: The Metro Atlanta Heart Disease Study. Ethn Dis. 2005;15:585–593
  42. Lewis TT, Everson-Rose SA, Powell LH, Matthews KA, Brown C, Karavolos K, et al. Chronic exposure to everyday discrimination and coronary artery calcification in African-American women: The SWAN Heart Study. Psychom Med. 2006;68:362–368
  43. Chae DH, Nuru-Jeter AM, Francis D, Lincoln KD. Conceptualizing racial disparities in health: advancement of a socio-psychobiological approach. Du Bois Rev. 2011;8:63–77
  44. Heeringa SF, Wagner J, Torres M, Duan NH, Adams T, Berglund P. Sample designs and sampling methods for the Collaborative Psychiatric Epidemiology Studies (CPES). Int J Methods Psychiatr Res. 2004;13:221–240
  45. Jackson JS, Neighbors HW, Nesse RM, Trierweiler SJ, Torres M. Methodological innovations in the National Survey of American Life. Int J Methods Psychiatr Res. 2004;13:289–298
  46. Jackson JS, Torres M, Caldwell CH, Neighbors HW, Nesse RM, Taylor RJ, et al. The National Survey of American Life: A study of racial, ethnic and cultural influences on mental disorders and mental health. Int J Methods Psychiatr Res. 2004;13:196–207
  47. Williams DR, Yu Y, Jackson JS, Anderson NB. Racial differences in physical and mental health: socioeconomic status, stress, and discrimination. J Health Psychol. 1997;2:335–351
  48. Kessler RC, Ustün TB. The World Mental Health (WMH) Survey Initiative Version of the World Health Organization (WHO) Composite International Diagnostic Interview (CIDI). Int J Methods Psychiatr Res. 2004;13:93–121
  49. Kessler RC, Abelson J, Demler O, Escobar JI, Gibbon M, Guyer ME, et al. Clinical calibration of DSM-IV diagnoses in the World Mental Health (WMH) version of the World Health Organization (WHO) Composite International Diagnostic Interview (WMHCIDI). Int J Methods Psychiatr Res. 2004;13:122–139
  50. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed.. Washington, DC: American Psychiatric Association; 1994;
  51. Kessler RC, Wittchen H-U, Abelson JM, McGonagle K, Schwarz N, Kendler KS, et al. Methodological studies of the Composite International Diagnostic Interview (CIDI) in the US National Comorbidity Survey (NCS). Int J Methods Psychiatr Res. 1998;7:33–55
  52. Colditz GA, Martin P, Stampfer MJ, Willett WC, Sampson L, Rosner B, et al. Validation of questionnaire information on risk factors and disease outcomes in a prospective cohort study of women. Am J Epidemiol. 1986;123:894–900
  53. Harlow SD, Linet MS. Agreement between questionnaire data and medical records—the evidence for accuracy of recall. Am J Epidemiol. 1989;129:233–248
  54. Marlowe D, Crowne DP. Social desirability and response to perceived situational demands. J Consult Psychol. 1961;25:109–115
  55. Rubin DB. Multiple Imputation for Nonresponse in Surveys. New York: John Wiley and Sons; 1987;
  56. Schafer JL, Graham JW. Missing data: Our view of the state of the art. Psychol Meth. 2002;7:147–177
  57. Schafer JL. Analysis of Incomplete Multivariate Data. New York: Chapman and Hall; 1997;
  58. Allison PD. Multiple imputation for missing data—a cautionary tale. Sociol Meth Res. 2000;28:301–309
  59. Horton NJ, Lipsitz SF, Parzen M. A potential for bias when rounding in multiple imputation. Am Stat. 2003;57:229–232
  60. Bieler GS, Brown GG, Williams RL, Brogan DJ. Estimating model-adjusted risks, risk differences, and risk ratios from complex survey data. Am J Epidemiol. 2010;171:618–623
  61. Jaccard J. Interaction Effects in Logistic Regression. Thousand Oaks, CA: Sage Publication; 2001;
  62. Klonoff EA, Landrine H, Ullman JB. Racial discrimination and psychiatric symptoms among blacks. Cult Div Ethn Min Psychol. 1999;5:329–339
  63. Schulz AJ, Gravlee CC, Williams DR, Israel BA, Mentz G, Rowe Z. Discrimination, symptoms of depression, and self-rated health among African American women in Detroit: Results from a longitudinal analysis. Am J Public Health. 2006;97:1265–1270
  64. Williams DR, Williams-Morris R. Racism and mental health: The African American experience. Ethn Health. 2000;5:243–268
  65. Lazarus RS, Folkman S. Stress, Appraisal, and Coping. New York: Springer; 1984;

 The National Survey of American Life is supported by the National Institute of Mental Health (NIMH; grant U01-MH57716; P.I.: J. S. Jackson) with supplemental support from the Office of Behavioral and Social Science Research at the National Institutes of Health and the University of Michigan.

PII: S1047-2797(11)00313-9

doi: 10.1016/j.annepidem.2011.10.009

Annals of Epidemiology
Volume 22, Issue 2 , Pages 104-111 , February 2012

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